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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Brain connectivity and metacognition in persons with subjective cognitive decline (COSCODE): rationale and study design

Fig. 1

Clinical and research workups. The figure shows the clinical workup of the GMC and the research workup of COSCODE. During the first visit, sociodemographic features, general health, and global cognition (MMSE, Clock test, Three-Objects-Three-Places) are evaluated. In this visit, medical, family history, and medication information are collected, and a neurological exam is performed. Visit 2 consists of a complete neuropsychological assessment. Visit 3 includes scales and questionnaires on psychological health, lifestyles, and some additional cognitive tests. After Visit 3, the individual comes back to the GMC for a diagnostic restitution with a physician and a neuropsychologist. In this session, the COSCODE project will be proposed. During the COSCODE workup, the metacognition task, scales, and questionnaires on metacognition will be administered. Stool and saliva will be collected for all participants. 60 participants will undergo 7T MRI. Amyloid and tau PET, as well as actigraphy will be performed on around 60% of the sample. Behavioral follow-up at 1 and 2 years will be done for all participants

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