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Table 3 Association of blood-borne factors with long-term forgetting rates

From: Association of accelerated long-term forgetting and senescence-related blood-borne factors in asymptomatic individuals from families with autosomal dominant Alzheimer’s disease

Dependent variables   Independent factors B B SE β p value R2
The whole sample
 Forgetting rate in list recall Step 1 Age 0.84 0.24 0.51 0.001 0.24
  Step 2 Age 0.97 0.23 0.59 < 0.001 0.33
   THBS4 −0.07 0.03 −0.34 0.020  
  Step 3 Age 1.14 0.22 0.69 < 0.001 0.43
   THBS4 −0.10 0.03 −0.46 0.002  
   Sex −10.53 3.93 −0.36 0.011  
 Forgetting rate in figure recall Step 1 GDF11 0.17 0.06 0.44 0.006 0.17
  Step 2 GDF11 0.15 0.05 0.38 0.011 0.28
   THBS4 −0.08 0.03 −0.36 0.016  
  Step 3 GDF11 0.15 0.05 0.39 0.007 0.34
   THBS4 −0.10 0.03 −0.44 0.004  
   Sex −8.94 4.35 −0.29 0.048  
 Forgetting rate in list recognition Step 1 CCL11 0.20 0.06 0.46 0.003 0.19
  Step 2 CCL11 0.20 0.06 0.47 0.002 0.30
   THBS4 −0.05 0.02 −0.30 0.042  
  Step 3 CCL11 0.19 0.06 0.44 0.002 0.35
   THBS4 −0.06 0.02 −0.37 0.010  
   Age 0.42 0.18 0.32 0.025  
Mutation carriers
 Forgetting rate in list recall   Age 1.16 0.33 0.67 0.003 0.41
 Forgetting rate in figure recall   GDF11 0.17 0.06 0.59 0.012 0.31
Non-carriers
 Forgetting rate in list recall   MCP1 0.10 0.03 0.66 0.001 0.41
 Forgetting rate in figure recall   THBS4 −0.05 0.02 −0.44 0.046 0.15
 Forgetting rate in list recognition   CCL11 0.20 0.08 0.49 0.025 0.20
  1. Results of multivariate linear regression analysis (stepwise) with the age, sex, education, and blood-borne factors as independent factors, and the long-term forgetting rates as dependent variables. Only statistically significant associations are listed (p  <  0.05)
  2. Abbreviations: CCL11 CC chemokine ligand 11, GDF11 growth differentiation factor 11, MCP1 monocyte chemotactic protein 1, THBS4 thrombospondin-4