Association of accelerated long-term forgetting and senescence-related blood-borne factors in asymptomatic individuals from families with autosomal dominant Alzheimer’s disease

Table 3 Association of blood-borne factors with long-term forgetting rates

Dependent variables		Independent factors	B	B SE	β	p value	R²
The whole sample
Forgetting rate in list recall	Step 1	Age	0.84	0.24	0.51	0.001	0.24
	Step 2	Age	0.97	0.23	0.59	< 0.001	0.33
		THBS4	−0.07	0.03	−0.34	0.020
	Step 3	Age	1.14	0.22	0.69	< 0.001	0.43
		THBS4	−0.10	0.03	−0.46	0.002
		Sex	−10.53	3.93	−0.36	0.011
Forgetting rate in figure recall	Step 1	GDF11	0.17	0.06	0.44	0.006	0.17
	Step 2	GDF11	0.15	0.05	0.38	0.011	0.28
		THBS4	−0.08	0.03	−0.36	0.016
	Step 3	GDF11	0.15	0.05	0.39	0.007	0.34
		THBS4	−0.10	0.03	−0.44	0.004
		Sex	−8.94	4.35	−0.29	0.048
Forgetting rate in list recognition	Step 1	CCL11	0.20	0.06	0.46	0.003	0.19
	Step 2	CCL11	0.20	0.06	0.47	0.002	0.30
		THBS4	−0.05	0.02	−0.30	0.042
	Step 3	CCL11	0.19	0.06	0.44	0.002	0.35
		THBS4	−0.06	0.02	−0.37	0.010
		Age	0.42	0.18	0.32	0.025
Mutation carriers
Forgetting rate in list recall		Age	1.16	0.33	0.67	0.003	0.41
Forgetting rate in figure recall		GDF11	0.17	0.06	0.59	0.012	0.31
Non-carriers
Forgetting rate in list recall		MCP1	0.10	0.03	0.66	0.001	0.41
Forgetting rate in figure recall		THBS4	−0.05	0.02	−0.44	0.046	0.15
Forgetting rate in list recognition		CCL11	0.20	0.08	0.49	0.025	0.20

Results of multivariate linear regression analysis (stepwise) with the age, sex, education, and blood-borne factors as independent factors, and the long-term forgetting rates as dependent variables. Only statistically significant associations are listed (p < 0.05)
Abbreviations: CCL11 CC chemokine ligand 11, GDF11 growth differentiation factor 11, MCP1 monocyte chemotactic protein 1, THBS4 thrombospondin-4

ISSN: 1758-9193