Table 3 Median (range) change from baseline to week 24 in plasma biomarkers by Ctrough plasma neflamapimod levels on day 21 versus placebo
Biomarker | Placebo (N = 67) | Neflamapimod by Ctrough | P value for downward trend1 | |
|---|---|---|---|---|
≤ 75% Percentile (N = 42) | > 75% Percentile (N = 13) | |||
Total tau | 7.0 (−84.2, 489.2) | 2.9 (−68.4, 48.4) | 3.6 (−30.7, 22.8) | 0.04 |
P-tau181 | 0.67 (−6.4, 44.0) | 0.03 (−5.5, 6.8) | 0.06 (−4.2, 3.0) | 0.02 |
Aβ1-40 | 221 (−6753, 4988) | 465 (−6017, 8524) | 126 (−2070, 2568) | 0.24 |
Aβ1-42 | −1.6 (−150, 268) | 5.5 (−298, 205) | −37.7 (−136, 92) | 0.05 |
Neurogranin | 9.1 (−128, 481) | −0.65(−124, 323) | 11.3 (−44, 75) | 0.1 |
Neurofilament light chain | 60 (−655, 3933) | 42 (−1417, 513) | 53 (−322, 665) | 0.16 |