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Fig. 4 | Alzheimer's Research & Therapy

Fig. 4

From: Repurposing beta-3 adrenergic receptor agonists for Alzheimer’s disease: beneficial effects in a mouse model

Fig. 4

β3AR stimulation reduces insoluble Aβ42/Aβ40 ratio in the hippocampus of 3xTg-AD mice. Human Aβ40 and Aβ42 peptides measured by ELISA in the a, b detergent-soluble and in the d, e detergent-insoluble fractions of hippocampus homogenates of 3xTg-AD mice, respectively. c Ratio of detergent-soluble and f detergent-insoluble Aβ42 on Aβ40 peptides in the hippocampus. Data are represented as mean ± SEM (n/group indicated in bars). Statistics: Unpaired Student’s t test: #p < 0.05 (a–e). Abbreviations: 3xTg-AD: triple transgenic mice; Aβ: amyloid-β; CL: CL-316,243-injected group; NonTg: non-transgenic mice; S: saline-injected group

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Alzheimer's Research & Therapy

ISSN: 1758-9193