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Table 2 The association of neurodegenerative pathologies in the MTL with MTL volume/thickness measures in β-amyloid negative individuals. All pathologies are entered in one model, with time between scan and death and gender as covariates. Spearman rank values are reported in the table

From: Pathological drivers of neurodegeneration in suspected non-Alzheimer’s disease pathophysiology

  Whole Hippo Ant Hippo Post Hippo ERC BA35 BA36 PHC
ADNI
 NP −0.11 −0.12 0.08 0.14 −0.13 −0.14 −0.31
 Tau 0.02 0.09 −0.17 −0.31 −0.11 0.08 0.05
 α-synuclein 0.00 −0.08 0.35 0.23 0.22 −0.08 0.26
 TDP-43 −0.48 −0.40 −0.41 0.00 0.14 0.57 0.49
UPenn
 NP 0.16 0.14 0.13 0.20 0.17 0.09 0.32*
 Tau 0.40** 0.34* 0.46*** 0.34* 0.31* −0.29 −0.08
 α-synuclein −0.10 −0.03 −0.13 −0.11 −0.14 −0.16 −0.15
 TDP-43 0.30* 0.33* −0.26 −0.13 −0.25 −0.22 −0.11
  1. p<0.10, *p<0.05, **p<0.01, ***p<0.001. NP neuritic plaques, TDP TAR DNA-binding protein, Ant anterior, Post posterior, ERC entorhinal cortex, BA Brodmann area, PHC parahippocampal cortex