Table 1 Sample characteristics
From: Characterization of Alzheimer’s tau biomarker discordance using plasma, CSF, and PET
Characteristics | Plasma/CSF group | Plasma/PET group | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Plasma−/CSF− | Plasma+/CSF− | Plasma−/CSF+ | Plasma+/CSF+ | P | Plasma−/PET– | Plasma+/PET− | Plasma−/PET+ | Plasma+/PET+ | P | |
Numbers (%) | 345 (51.6) | 104 (15.6) | 102 (15.3) | 117 (17.5) | 151 (61.6) | 55 (22.4) | 15 (6.1) | 24 (9.8) | ||
Age (years) | 70.34 (6.58) | 73.06 (7.18) | 73.90 (7.13) | 74.28 (6.72) | <0.001 | 70.43 (6.42) | 73.56 (7.12) | 73.05 (5.64) | 73.03 (7.45) | 0.011 |
Female (%) | 170 (49.3) | 39 (37.5) | 52 (51.0) | 61 (52.1) | 0.113 | 74 (49.0) | 21 (38.2) | 7 (46.7) | 15 (62.5) | 0.239 |
Educational years | 16.43 (2.51) | 16.34 (2.78) | 16.50 (2.56) | 16.15 (2.59) | 0.735 | 16.32 (2.73) | 16.49 (2.68) | 16.53 (2.23) | 15.38 (2.75) | 0.360 |
APOE Ɛ4 (%) | 95 (27.5) | 45 (43.3) | 52 (51.0) | 81 (69.2) | <0.001 | 42 (27.8) | 24 (43.6) | 10 (66.7) | 11 (45.8) | 0.005 |
Diagnosis | ||||||||||
CN | 157 (45.5) | 34 (32.7) | 38 (37.3) | 23 (19.7) | <0.001 | 83 (55.0) | 29 (52.7) | 3 (20.0) | 7 (29.2) | 0.011 |
MCI | 188 (54.5) | 70 (67.3) | 64 (62.7) | 94 (80.3) | 68 (45.0) | 26 (47.3) | 12 (80.0) | 17 (70.8) | ||
CSF Aβ42 (pg/ml) | 1347.37 (568.07) | 1080.68 (591.37) | 1210.44 (732.29) | 831.29 (409.36) | <0.001 | 1470.49 (600.76) | 1121.27 (607.10) | 892.15 (487.98) | 776.61 (383.27) | <0.001 |
Aβ-PET SUVR | 0.78 (0.08) | 0.86 (0.15) | 0.90 (0.14) | 1.01 (0.11) | <0.001 | 0.77 (0.07) | 0.81 (0.09) | 0.99 (0.12) | 0.98 (0.13) | <0.001 |
Aβ+ (%) | 129 (37.4) | 66 (63.5) | 65 (63.7) | 99 (84.6) | <0.001 | 44 (31.2) | 27 (57.4) | 11 (78.6) | 22 (95.7) | <0.001 |
Plasma to PET (years) | – | – | – | – | – | 1.60 (0.98) | 1.62 (0.97) | 1.60 (1.12) | 1.83 (1.13) | 0.759 |