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Table 3 Descriptive statistics of demographics and baseline scores MMSE, Verbal Fluency (animals), and ADAScog (11 subtests)

From: Using historical data to facilitate clinical prevention trials in Alzheimer disease? An analysis of longitudinal MCI (mild cognitive impairment) data sets

 

ADNI

n = 395

NACC

n = 4328

InDDEx

n = 831

CNG

n = 726

BS-MC

n = 1558

Age (\( \overline{x}\pm SD \))

74.2±7.5

74.4±7.9

70.1±7.6

68.0±7.9

69.7±9.1

Education (\( \overline{x}\pm SD \))

15.7±3.0

15.2±3.0

11.8±3.5

12.3±2.8

12.0±3.1

Female, n (%)

141 (35.7)

2113 (48.8)

422 (49.05)

332 (45.7)

713 (45.8)

ApoE4a

 1 allele no (%)

 2 alleles no (%)

nApoE=395

165 (41.8)

47 (11.9)

nApoE=2523

951 (37.7)

219 (8.7)

nApoE=396

131 (32.3)

39 (9.6)

nApoE=577

200 (34.7)

200 (34.7)

nApoE=53

22 (41.5)

5 (9.4)

MMSE (\( \overline{x}\pm SD \))

Minb-max

27.0±1.8

23–30

27.0±2.4

2–30

27.2±2.5

16–30

27.1±2.1

17–30

27.4±2.3

14–30

Verb. Fl. (\( \overline{x}\pm SD \))

Min-max

15.9±4.9

5–30

16.0±5.0

0–35

17.5±5.9

2–38

17.5±5.5

3–32

17.4±5.5

3–38

ADAScog (\( \overline{x}\pm SD \))

min-max

11.5±4.4

2–27.7

-

10.0±4.7

1–27

11.7±5.1

0–35

-

  1. aApoE was not determined in all patients, number of evaluations is given as nApoE, percent of ApoE evaluations shown in parentheses. bMMSE is below inclusion criterions 24 in ADNI (n=1) and below 20 in CNG (n=5)