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Table 3 Descriptive statistics of demographics and baseline scores MMSE, Verbal Fluency (animals), and ADAScog (11 subtests)

From: Using historical data to facilitate clinical prevention trials in Alzheimer disease? An analysis of longitudinal MCI (mild cognitive impairment) data sets

  ADNI
n = 395
NACC
n = 4328
InDDEx
n = 831
CNG
n = 726
BS-MC
n = 1558
Age (\( \overline{x}\pm SD \)) 74.2±7.5 74.4±7.9 70.1±7.6 68.0±7.9 69.7±9.1
Education (\( \overline{x}\pm SD \)) 15.7±3.0 15.2±3.0 11.8±3.5 12.3±2.8 12.0±3.1
Female, n (%) 141 (35.7) 2113 (48.8) 422 (49.05) 332 (45.7) 713 (45.8)
ApoE4a
 1 allele no (%)
 2 alleles no (%)
nApoE=395
165 (41.8)
47 (11.9)
nApoE=2523
951 (37.7)
219 (8.7)
nApoE=396
131 (32.3)
39 (9.6)
nApoE=577
200 (34.7)
200 (34.7)
nApoE=53
22 (41.5)
5 (9.4)
MMSE (\( \overline{x}\pm SD \))
Minb-max
27.0±1.8
23–30
27.0±2.4
2–30
27.2±2.5
16–30
27.1±2.1
17–30
27.4±2.3
14–30
Verb. Fl. (\( \overline{x}\pm SD \))
Min-max
15.9±4.9
5–30
16.0±5.0
0–35
17.5±5.9
2–38
17.5±5.5
3–32
17.4±5.5
3–38
ADAScog (\( \overline{x}\pm SD \))
min-max
11.5±4.4
2–27.7
- 10.0±4.7
1–27
11.7±5.1
0–35
-
  1. aApoE was not determined in all patients, number of evaluations is given as nApoE, percent of ApoE evaluations shown in parentheses. bMMSE is below inclusion criterions 24 in ADNI (n=1) and below 20 in CNG (n=5)