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Table 1 Inclusion and exclusion criteria for the diagnosis of MCI used in five studies

From: Using historical data to facilitate clinical prevention trials in Alzheimer disease? An analysis of longitudinal MCI (mild cognitive impairment) data sets

  Eligibility Inclusion Exclusion
Age MMSE Other, medication Functional impairment Cognitive impairment Depression Other/vascular
ADNI 55–90 24–30 Stable medication, AChEIs, memantine admitted, 6 grades education or work history No functional impairment, but many with high FAQ scores. CDR=0.5; memory ≥ 0.5 Memory complaint LogMem II, dependent on education Geriatric Depression Scale ≥6 Hachinski Ischemic Score IS >5
NACC -- -- Similar to ADNI Essentially normal daily functions Cognitive complaint, cognitive decline (clinician's diagnosis) Not specified Not specified
InDDEx 55–85 -- No AChEI in previous 2 weeks, no rivastigmine in previous 4 weeks Cognitive symptoms (not specified); CDR=0.5 NYU delayed paragraph recall<9 HDRS>12, HDRS item1 > 1, DSM-IV major depression AD criteria from DSM-IV or NINCDS-ADRDA mod. Hachinski Ischemic Score>4
CNG ≥ 50 ≥ 20 A broader definition of MCI was used Complaint of cognitive deficit in daily living; minor changes were tolerated: B-ADL< 4 Decline of cog. abilities (>1 SD) in at least one neuropsychological domain Not specified Not specified
BS-MC N/A N/A Consecutively referred patients from GPs Essentially Winblad et al. [26] criteria; no significant functional decline Impairment (≤ −1.28 SD; age-, education-,and gender-adjusted) in ≥ one cognitive domain Probable cause for MCI other than early AD, based on comprehensive medical exam and neuroimaging results Not specified