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Table 4 Associations between BMI change and global WMHV, β-amyloid status and brain volumes at age 71

From: Investigating the relationship between BMI across adulthood and late life brain pathologies

 

Relative change in WMHV (95% CI)

β-amyloid adjusted OR (95% CI)

WBV β coefficient (95% CI)

Mean HV β coefficient (95% CI)

Model 1(c)

Model 2(c)

Model 1(c)

Model 2(c)

Model 1(c)

Model 2(c)

Model 1(c)

Model 2(c)

36–43 years

WMHV:

Model 1: n = 391

Model 2: n = 386

Amyloid:

Model 1: n = 394

Model 2: n = 387

WBV/HV:

Model 1: n = 383

Model 2: n = 378

1.08 (0.96, 1.21)

1.06 (0.94, 1.19)

1.08 (0.83, 1.41)

1.09 (0.83, 1.42)

0.9 (− 3.6, 5.5)

1.9 (− 2.8, 6.5)

− 0.006 (− 0.035, 0.023)

− 0.010 (− 0.039, 0.020)

43–53 years

WMHV:

Model 1: n = 391

Model 2: n = 387

Amyloid:

Model 1: n = 394

Model 2: n = 387

WBV/HV:

Model 1: n = 383

Model 2: n = 379

1.02 (0.91, 1.14)

0.99 (0.89, 1.11)

0.95 (0.74, 1.21)

0.95 (0.73, 1.25)

− 3.9 (− 8.3, 0.5)

− 1.5 (− 6.1, 3.0)

− 0.006 (− 0.033, 0.022)

0 (− 0.029, 0.029)

53–60/64 years

WMHV:

Model 1: n = 391

Model 2: n = 390

Amyloid:

Model 1: n = 394

Model 2: n = 391

WBV/HV:

Model 1: n = 383

Model 2: n = 382

1.06 (0.95, 1.18)

1.04 (0.93, 1.15)

0.85 (0.65, 1.11)

0.87 (0.66, 1.16)

− 4.2 (− 8.8, 0.4)

− 4.2 (− 8.7, 0.4)

0.009 (− 0.020, 0.038)

0.010 (− 0.019, 0.039)

60/64–69 years

WMHV:

Models 1 and 2: n = 391

Amyloid:

Model 1: n = 394

Model 2: n = 392

WBV/HV:

Models 1 and 2: n = 383

1.01 (0.91, 1.13)

0.99 (0.89, 1.11)

0.92 (0.71, 1.19)

0.93 (0.72, 1.20)

− 2.4 (− 6.8, 2.0)

− 2.4 (− 6.9, 2.1)

− 0.004 (− 0.032, 0.024)

− 0.006 (− 0.034, 0.023)

69–71 years

WMHV:

Model 1: n = 391

Model 2: n = 390

Amyloid:

Model 1: n = 394

Model 2: n = 391

WBV/HV:

Model 1: n = 383

Model 2: n = 382

1.01 (0.91, 1.11)

1.00 (0.90, 1.11)

0.75 (0.57, 0.97)

0.69 (0.52, 0.92)

0.1 (− 4.5, 4.6)

− 0.2 (− 4.7, 4.3)

0.002 (− 0.026, 0.031)

0.002 (− 0.027, 0.030)

  1. WMHV coefficients represent the relative change in mean WMHV per 1 SD increase in the expected BMI change across each time-interval using GLM. Adjusted amyloid ORs are quoted per 1 SD increase in the expected BMI change from logistic regression models. Brain volume β coefficients represent the change in brain volume (ml) per 1 SD increase in the expected BMI change from linear regression models. Associations significant at p < 0.05 are highlighted in bold. All model 1(c) analyses include all change variables in a single model and adjust for sex (β-amyloid analyses), TIV and scanning age (WMHV and brain volume analyses). Model 2(c) analyses examine each change variable separately and also adjust for contemporaneous SBP, DM, hypercholesterolaemia, adult SEP, smoking (WMHV models) and also β-amyloid status and global WMHV (brain volume analyses). β-amyloid model 2(c) analyses account for sex, contemporaneous SBP and APOE-ε4 status. BMI body mass index, CI confidence interval, DM diabetes mellitus, GLM generalised linear model, HV hippocampal volume, OR odds ratio, SBP systolic blood pressure, SD standard deviation, SEP socioeconomic position, TIV total intracranial volume, WBV whole brain volume, WMHV white matter hyperintensity volume
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Alzheimer's Research & Therapy

ISSN: 1758-9193