Cohort 1 | |||
---|---|---|---|
DC (n = 72) | AD (n = 54) | p-value AD - DC | |
Age | 69.71 ± 10.68 | 72.76 ± 10.91 | 0.1184* |
Gender | 0.0057$ | ||
Women | 35 (48.6%) | 40 (74.1%) | |
Men | 37 (51.2%) | 14 (25.9%) | |
CSF GPNMB [pg/ml] | 9806 ± 4006 | 11270 ± 4957 | 0.0788# |
APOE genotype | |||
ε2/ε2 | – | 1 | |
ε2/ε3 | 10 | 4 | |
ε2/ε4 | 2 | 3 | |
ε3/ε3 | 44 | 12 | |
ε3/ε4 | 15 | 29 | |
ε4/ε4 | 1 | 5 | |
≥ 1 APOE ε4 allele, n (%) | 18 (25%) | 37 (68.5%) | < 0.0001$ |
CSF p-Tau [pg/ml]* | 47.47 ± 18.89 | 111.5 ± 46.66 | < 0.0001# |
CSF t-Tau [pg/ml]* | 257.1 ± 91.43 | 760.2 ± 310.2§ | < 0.0001# |
CSF Aβ38 [pg/ml]* | 2271 ± 997.3 | 2543 ± 889.4 | 0.0902# |
CSF Aβ40 [pg/ml]* | 6871 ± 3050 | 7614 ± 2875 | 0.1843# |
CSF Aβ42 [pg/ml]* | 709.2 ± 394 | 359.7 ± 141.6 | < 0.0001# |
CSF Aβ 42/40* | 0.0994 ± 0.0231 | 0.0478 ± 0.0104 | < 0.0001* |