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Table 2 Top 20 candidate repositioning drugs for Alzheimer’s disease

From: Artificial intelligence-based computational framework for drug-target prioritization and inference of novel repositionable drugs for Alzheimer’s disease

DRUG Overlaps between known targets and predicted targets # of overlaps
Regorafenib RET; FLT1; KDR; KIT; PDGFRA; PDGFRB; FGFR1; TEK; NTRK1; EPHA2; ABL1 11
Tamoxifen ESR1; ESR2; PRKCA; PRKCB; PRKCD; PRKCE; PRKCG; PRKCQ; PRKCZ; ESRRG 10
Ponatinib ABL1; KIT; RET; TEK; FGFR1; LCK; SRC; LYN; KDR; PDGFRA 10
Dasatinib ABL1; SRC; FYN; LCK; KIT; PDGFRB; EPHA2; BTK; FGR; LYN 10
Imatinib PDGFRB; ABL1; KIT; RET; NTRK1; CSF1R; PDGFRA 7
Brigatinib EGFR; ABL1; IGF1R; INSR; MET; ERBB2 6
Sorafenib PDGFRB; KIT; KDR; FGFR1; RET; FLT1 6
Sunitinib PDGFRB; FLT1; KDR; KIT; CSF1R; PDGFRA 6
Nintedanib FLT1; KDR; FGFR1; LCK; LYN; SRC 6
Pazopanib FLT1; KDR; PDGFRA; PDGFRB; KIT 5
Midostaurin PRKCA; KDR; KIT; PDGFRA; PDGFRB 5
Resveratrol ITGA5; ITGB3; SNCA; ESR1; AKT1 5
Diethylstilbestrol ESR1; ESRRG; ESR2; ESRRA 4
Tofacitinib TYK2; JAK2; JAK1; JAK3 4
Lenvatinib FLT1; KDR; FGFR1; KIT 4
Foreskin fibroblast (neonatal) FLT1; CSF2RA; PDGFRB; TGFB1 4
Baricitinib JAK1; JAK2; PTK2B; JAK3 4
Foreskin keratinocyte (neonatal) EGFR; CSF2RA; PDGFRA; TGFB1 4
Bosutinib ABL1; LYN; SRC 3
Estradiol valerate ESR1; ESR2; ESRRG 3