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Table 2 Top 20 candidate repositioning drugs for Alzheimer’s disease

From: Artificial intelligence-based computational framework for drug-target prioritization and inference of novel repositionable drugs for Alzheimer’s disease

DRUG

Overlaps between known targets and predicted targets

# of overlaps

Regorafenib

RET; FLT1; KDR; KIT; PDGFRA; PDGFRB; FGFR1; TEK; NTRK1; EPHA2; ABL1

11

Tamoxifen

ESR1; ESR2; PRKCA; PRKCB; PRKCD; PRKCE; PRKCG; PRKCQ; PRKCZ; ESRRG

10

Ponatinib

ABL1; KIT; RET; TEK; FGFR1; LCK; SRC; LYN; KDR; PDGFRA

10

Dasatinib

ABL1; SRC; FYN; LCK; KIT; PDGFRB; EPHA2; BTK; FGR; LYN

10

Imatinib

PDGFRB; ABL1; KIT; RET; NTRK1; CSF1R; PDGFRA

7

Brigatinib

EGFR; ABL1; IGF1R; INSR; MET; ERBB2

6

Sorafenib

PDGFRB; KIT; KDR; FGFR1; RET; FLT1

6

Sunitinib

PDGFRB; FLT1; KDR; KIT; CSF1R; PDGFRA

6

Nintedanib

FLT1; KDR; FGFR1; LCK; LYN; SRC

6

Pazopanib

FLT1; KDR; PDGFRA; PDGFRB; KIT

5

Midostaurin

PRKCA; KDR; KIT; PDGFRA; PDGFRB

5

Resveratrol

ITGA5; ITGB3; SNCA; ESR1; AKT1

5

Diethylstilbestrol

ESR1; ESRRG; ESR2; ESRRA

4

Tofacitinib

TYK2; JAK2; JAK1; JAK3

4

Lenvatinib

FLT1; KDR; FGFR1; KIT

4

Foreskin fibroblast (neonatal)

FLT1; CSF2RA; PDGFRB; TGFB1

4

Baricitinib

JAK1; JAK2; PTK2B; JAK3

4

Foreskin keratinocyte (neonatal)

EGFR; CSF2RA; PDGFRA; TGFB1

4

Bosutinib

ABL1; LYN; SRC

3

Estradiol valerate

ESR1; ESR2; ESRRG

3