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Table 2 Association between lifestyle factors and AD biomarkers

From: Associations of healthy lifestyles with cerebrospinal fluid biomarkers of Alzheimer’s disease pathology in cognitively intact older adults: the CABLE study

 

Current smoking

P*

P#

Yes (n = 220)

No (n = 888)

CSF Aβ42

162.25 ± 71.75

169.01 ± 81.40

0.47

0.17

CSF tau

170.81 ± 70.35

171.43 ± 77.54

0.78

0.29

CSF p-tau

36.57 ± 8.57

36.89 ± 9.23

0.83

0.47

 

Alcohol consumption

  

Harmful drinking (n = 157)

No or moderate drinking (n = 951)

  

CSF Aβ42

178.53 ± 94.72

165.82 ± 76.65

0.35

0.44

CSF tau

175.84 ± 80.03

170.55 ± 75.48

0.63

0.12

CSF p-tau

37.11 ± 10.00

36.79 ± 8.95

0.97

0.35

 

Absence of social isolation

  

No (n = 240)

Yes (n = 868)

  

CSF Aβ42

175.89 ± 89.94

165.33 ± 76.30

0.27

0.19

CSF tau

188.17 ± 76.40

166.67 ± 75.44

< 0.01

< 0.01

CSF p-tau

39.11 ± 9.09

36.21 ± 9.01

< 0.01

< 0.01

 

Regular physical activity

  
 

No (n = 833)

Yes (n = 275)

  

CSF Aβ42

163.96 ± 76.65

178.96 ± 87.03

0.03

0.01

CSF tau

173.73 ± 78.20

164.03 ± 69.15

0.10

0.04

CSF p-tau

37.25 ± 9.32

35.57 ± 8.28

0.01

< 0.01

  1. *Unadjusted
  2. #Adjusted for age, sex, educational level, and APOE ε4 status