Table 1 Descriptive composition of included subjects in terms of baseline amyloid status, APOE-ε4 carriership, sex, age, and annualized accumulation rates in DVR and SUVR

Number of subjects (%)

237 (100)

159 (67.1)

78 (32.9)

194 (81.8)

146 (75.2)

48 (24.8)

20 (8.44)

5 (25.0)

15 (75.0)

23 (9.70)

8 (34.8)

15 (65.2)

Number of women (%)

154 (65.0)

100 (62.9)

54 (69.2)

129 (66.5)

95 (65.1)

34 (70.8)

13 (65.0)

1 (20.0)

12 (80.0)

12 (52.2)

4 (50.0)

8 (53.3)

Age, years

65.3 ± 9.4

65.8 ± 9.5

64.5 ± 9.2

64.4 ± 9.6

65.3 ± 9.7

61.7 ± 9.2

67.6 ± 7.4

67.7 ± 3.9

67.6 ± 8.3

71.1 ± 6.6

72.4 ± 7.0

70.3 ± 6.5

 Baseline (IQR)

1.08 (1.05–1.14)

1.07 (1.05–1.12)

1.15 (1.05–1.44)

1.07 (1.04–1.11)

1.07 (1.04–1.10)

1.07 (1.04–1.14)

1.40 (1.29–1.45)

1.38 (1.30–1.47)

1.41 (1.28–1.45)

1.73 (1.61–1.91)

1.79 (1.59–1.91)

1.72 (1.61–1.91)

 Annual % change

1.06 (1.30)

0.77 (1.08)

1.63 (1.53)

0.80 (1.18)

0.69 (0.99)

1.15 (1.56)

2.83 (0.93)

2.81 (0.69)

2.84 (1.02)

1.77 (1.18)

2.37 (1.34)

1.98 (1.07)

 Effect size

0.76

0.69

1.10

0.69

0.63

0.72

3.54

4.75

3.00

1.58

1.05

1.89

 Number of accumulators (%) [CUs TRT]

45 (23.6)

25 (15.7)

31 (39.7)

27 (13.9)

17 (11.6)

10 (20.8)

17 (85.0)

5 (100.0)

12 (80.0)

12 (52.2)

3 (37.5)

9 (60.0)

 Number of accumulators (%) [ALL TRT]

20 (8.4)

5 (3.1)

15 (19.2)

10 (5.2)

3 (2.1)

7 (14.6)

7 (35.0)

1 (20.0)

6 (40.0)

3 (13.0)

1 (12.5)

2 (13.3)

 Baseline (IQR)

1.16 (1.08–1.23)

1.14 (1.11–1.18)

1.22 (1.13–1.54)

1.14 (1.11–1.18)

1.14 (1.11–1.17)

1.15 (1.11–1.20)

1.50 (1.41–1.54)

1.50 (1.42–1.53)

1.50 (1.38–1.55)

1.79 (1.73–1.99)

1.89 (1.78–2.03)

1.79 (1.71–1.98)

 Annual % change

1.25 (1.26)

0.99 (1.08)

1.75 (1.44)

1.02 (1.16)

0.91 (1.03)

1.34 (1.44)

2.87 (1.02)

2.74 (0.90)

2.90 (1.08)

1.74 (1.13)

1.36 (1.17)

1.94 (1.09)

 Effect size

0.94

0.86

1.20

0.86

0.87

0.94

3.23

3.41

3.00

1.55

1.18

1.84

 Baseline (IQR)

1.05 (1.02–1.10)

1.04 (1.01–1.07)

1.10 (1.03–1.30)

1.04 (1.01–1.06)

1.04 (1.01–1.06)

1.04 (1.02–1.09)

1.26 (1.21–1.30)

1.29 (1.21–1.34)

1.25 (1.20–1.30)

1.54 (1.43–1.69)

1.59 (1.44–1.71)

1.53 (1.43–1.69)

 Annual % change

0.75 (1.11)

0.50 (0.91)

1.25 (1.30)

0.49 (0.96)

0.40 (0.82)

0.75 (1.29)

2.34 (0.72)

2.53 (0.43)

2.34 (0.80)

1.55 (0.93)

1.16 (1.07)

1.76 (0.80)

 Effect size

0.69

0.54

1.00

0.48

0.50

0.57

3.75

7.11

3.22

1.86

1.06

2.25

 Number of accumulators (%) [CUs TRT]

81 (34.2)

39 (24.5)

42 (53.8)

44 (22.7)

29 (19.9)

15 (31.3)

20 (100.0)

5 (100.0)

15 (100.0)

17 (73.9)

5 (62.5)

12 (80.0)

 Number of accumulators (%) [ALL TRT]

33 (13.9)

11 (6.9)

22 (28.2)

13 (6.7)

6 (4.1)

7 (14.6)

13 (65.0)

4 (80.0)

9 (60.0)

7 (30.4)

1 (12.5)

6 (40.0)

 Baseline (IQR)

1.11 (1.08–1.17)

1.10 (1.07–1.13)

1.16 (1.09–1.38)

1.09 (1.07–1.12)

1.09 (1.07–1.12)

1.10 (1.07–1.14)

1.34 (1.31–1.39)

1.39 (1.32–1.41)

1.34 (1.27–1.38)

1.66 (1.54–1.77)

1.72 (1.56–1.82)

1.59 (1.51–1.70)

 Annual % change

0.94 (1.08)

0.72 (0.94)

1.34 (1.22)

0.71 (0.97)

0.63 (0.87)

0.94 (1.19)

2.49 (0.76)

2.55 (0.71)

2.47 (0.80)

1.50 (0.89)

1.15 (0.96)

1.68 (0.83)

    Effect size

0.78

0.72

1.12

0.72

0.70

0.76

3.67

3.89

3.43

1.71

1.19

2.17