Skip to main content

Table 4 Weighted proportion of prescription pain medication use among older patients with chronic pain and with or without ADRD by residential setting

From: Quality of opioid prescribing in older adults with or without Alzheimer disease and related dementia

Medication Community   Nursing home
Weighted proportion among patients with ADRD, % Weighted proportion among patients without ADRD, % Proportion difference
(95% CI)a
P-value Weighted proportion among patients with ADRD, % Weighted proportion among patients without ADRD, % Proportion difference
(95% CI)a
P-value
Any use of prescription pain medicationb,c 66.6 67.6 − 1.0 (− 1.4 to − 0.7) < .001 64.5 74.9 − 10.4 (− 11.7 to − 9.1) < .001
Opioid
 Any use 45.1 48.1 − 3.0 (− 3.4 to − 2.6) < .001 47.9 60.7 − 12.8 (− 14.2 to − 11.3) < .001
 Long-term use of opioidd 41.2 35.7 5.4 (4.9 to 6.0) < .001 52.5 58.2 − 5.7 (−7.6 to − 3.8) < .001
Non-opioid
 Any use 30.3 32.7 − 2.4 (− 2.8 to − 2.1) < .001 18.0 21.9 − 3.9 (− 5.1 to − 2.7) < .001
Adjuvant analgesic
 Any use 35.9 32.7 3.1 (2.8 to 3.5) < .001 33.2 40.9 − 7.6 (− 9.1 to − 6.2) < .001
 SNRI or tricyclic antidepressant 40.0 26.8 13.1 (12.7 to 13.5) < .001 59.4 53.3 6.1 (4.6 to 7.6) < .001
 Anticonvulsant 21.1 17.7 3.4 (3.1 to 3.7) < .001 21.9 27.2 − 5.3 (− 6.7 to − 4.0) < .001
 Skeletal muscle relaxant 14.2 15.6 − 1.4 (− 1.7 to − 1.2) < .001 8.2 14.8 − 6.7 (− 7.7 to − 5.6) < .001
Topical analgesice 8.1 6.6 1.5 (1.3 to 1.7) < .001 8.8 11.9 − 3.0 (− 4.0 to − 2.1) < .001
  1. Abbreviations: ADRD Alzheimer disease and related dementias, SNRI serotonin-norepinephrine reuptake inhibitor
  2. aProportion difference between patients with or without ADRD was estimated with generalized linear models with weight statement (to incorporate inverse probability weighting that balances differences in baseline characteristics between the ADRD and non-ADRD groups)
  3. bUse of prescription pain medications was measured during the 12 months after diagnosis of chronic pain, which was randomly selected per patient
  4. cA patient may have more than 1 type of drug combination during the 12-month observation period
  5. dThe proportion was calculated among opioid users
  6. ePrescription topical analgesics included diclofenac and lidocaine