ATN class (n) | Time point | Difference in MMSE relative to baseline value | 95% CI | t | P |
A−/T−/N− (n = 73) | Time 6 | 0.53 | −0.59, 1.66 | 0.91 | 0.3629 |
Time 12 | 0.03 | −1.07, 1.13 | 0.05 | 0.9640 | |
Time 18 | −0.05 | −1.22, 1.12 | − 0.08 | 0.9343 | |
Time 24 | −0.86 | −1.99, 0.27 | − 1.47 | 0.1417 | |
Time 30 | − 1.91 | −3.22, −0.60 | −2.81 | 0.0050 | |
Time 36 | −1.29 | − 2.60, 0.02 | − 1.90 | 0.0580 | |
ATN class (n) | Time point | Difference in MMSE relative to value predicted based on A−/T−/N− at that time point and baseline MMSE | 95% CI | t | P |
A+/T−/N− (n = 76) | Time 6 | −0.76 | −2.37, 0.85 | − 0.90 | 0.3662 |
Time 12 | −1.04 | − 2.55, 0.47 | − 1.33 | 0.1851 | |
Time 18 | −1.51 | −3.06, 0.04 | −1.88 | 0.0611 | |
Time 24 | −2.24 | −3.80, −0.68 | − 2.77 | 0.0058 | |
Time 30 | −1.87 | −3.57, −0.17 | −2.12 | 0.0347 | |
Time 36 | −1.96 | −3.73, −0.18 | −2.13 | 0.0339 | |
A+/T+/N+ (n = 39) | Time 6 | −1.35 | −3.18, 0.49 | −1.41 | 0.1583 |
Time 12 | −2.16 | −3.89, −0.42 | − 2.39 | 0.0169 | |
Time 18 | −3.97 | −5.77, −2.16 | −4.24 | 0.0000 | |
Time 24 | −3.71 | −5.58, −1.83 | − 3.81 | 0.0001 | |
Time 30 | −4.11 | −6.18, −2.05 | −3.84 | 0.0001 | |
Time 36 | −4.78 | −6.97, −2.58 | − 4.20 | 0.0000 | |
A+/T−/N+ (n = 27) | Time 6 | −0.39 | −2.73, 1.96 | −0.32 | 0.7500 |
Time 12 | −0.28 | −2.25, 1.68 | −0.28 | 0.7813 | |
Time 18 | −1.73 | −3.78, 0.32 | −1.63 | 0.1034 | |
Time 24 | −1.62 | −3.69, 0.46 | −1.50 | 0.1334 | |
Time 30 | −1.18 | −3.41, 1.05 | −1.02 | 0.3090 | |
Time 36 | −2.83 | −5.04, −0.62 | −2.47 | 0.0136 | |
A−/T−/N+ (n = 10) | Time 6 | −0.66 | −3.88, 2.56 | −0.40 | 0.6927 |
Time 12 | −1.76 | −4.70, 1.19 | −1.15 | 0.2504 | |
Time 18 | −2.08 | −5.31, 1.15 | −1.24 | 0.2148 | |
Time 24 | −5.25 | −9.36, −1.14 | −2.46 | 0.0140 | |
Time 30 | −8.79 | −15.39, −2.20 | −2.57 | 0.0103 | |
Time 36 | −4.76 | −9.65, 0.12 | −1.88 | 0.0605 |