Table 2 Difference in MMSE at different time points relative to the reference class (A−/T−/N−) and to the baseline MMSE using linear mixed-effects model with random slope

ATN class (n)

Time point

Difference in MMSE relative to baseline value

95% CI

t

P

 A−/T−/N− (n = 73)

Time 6

0.53

−0.59, 1.66

0.91

0.3629

Time 12

0.03

−1.07, 1.13

0.05

0.9640

Time 18

−0.05

−1.22, 1.12

− 0.08

0.9343

Time 24

−0.86

−1.99, 0.27

− 1.47

0.1417

Time 30

− 1.91

−3.22, −0.60

−2.81

0.0050

Time 36

−1.29

− 2.60, 0.02

− 1.90

0.0580

ATN class (n)

Time point

Difference in MMSE relative to value predicted based on A−/T−/N− at that time point and baseline MMSE

95% CI

t

P

 A+/T−/N− (n = 76)

Time 6

−0.76

−2.37, 0.85

− 0.90

0.3662

Time 12

−1.04

− 2.55, 0.47

− 1.33

0.1851

Time 18

−1.51

−3.06, 0.04

−1.88

0.0611

Time 24

−2.24

−3.80, −0.68

− 2.77

0.0058

Time 30

−1.87

−3.57, −0.17

−2.12

0.0347

Time 36

−1.96

−3.73, −0.18

−2.13

0.0339

 A+/T+/N+ (n = 39)

Time 6

−1.35

−3.18, 0.49

−1.41

0.1583

Time 12

−2.16

−3.89, −0.42

− 2.39

0.0169

Time 18

−3.97

−5.77, −2.16

−4.24

0.0000

Time 24

−3.71

−5.58, −1.83

− 3.81

0.0001

Time 30

−4.11

−6.18, −2.05

−3.84

0.0001

Time 36

−4.78

−6.97, −2.58

− 4.20

0.0000

 A+/T−/N+ (n = 27)

Time 6

−0.39

−2.73, 1.96

−0.32

0.7500

Time 12

−0.28

−2.25, 1.68

−0.28

0.7813

Time 18

−1.73

−3.78, 0.32

−1.63

0.1034

Time 24

−1.62

−3.69, 0.46

−1.50

0.1334

Time 30

−1.18

−3.41, 1.05

−1.02

0.3090

Time 36

−2.83

−5.04, −0.62

−2.47

0.0136

 A−/T−/N+ (n = 10)

Time 6

−0.66

−3.88, 2.56

−0.40

0.6927

Time 12

−1.76

−4.70, 1.19

−1.15

0.2504

Time 18

−2.08

−5.31, 1.15

−1.24

0.2148

Time 24

−5.25

−9.36, −1.14

−2.46

0.0140

Time 30

−8.79

−15.39, −2.20

−2.57

0.0103

Time 36

−4.76

−9.65, 0.12

−1.88

0.0605