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Table 4 Effects of HTL0018318 on the performance of the Milner maze test immediate condition

From: Safety, pharmacokinetics and exploratory pro-cognitive effects of HTL0018318, a selective M1 receptor agonist, in healthy younger adult and elderly subjects: a multiple ascending dose study

 

Younger adults

Elderly

Parameter

Day 1

Day 5

Day 10

Day 1

Day 5

Day 10

15 mg HTL0018318

 MMTImm: Expl Error

− 1.2

(− 6.1, 3.7)

p = 0.6303

ES = 0.23

− 1.8

(− 6.7, 3.1)

p = 0.4678

ES = 0.34

− 2.6

(− 7.5, 2.4)

p = 0.3050

ES = 0.49

− 6.1

(− 10.8, − 1.3)

p = 0.0133

ES = 1.15

− 11.5

(− 16.3, − 6.7)

p = <.0001

ES = 2.19

− 7.0

(− 11.8, − 2.1)

p = 0.0052

ES = 1.32

20 mg HTL0018318

 MMTImm: Expl Error

− 0.9

(− 5.9, 4.1)

p = 0.7204

ES = 0.17

− 0.4

(− 5.4, 4.6)

p = 0.8637

ES = 0.08

3.3

(− 1.7, 8.3)

p = 0.1930

ES = 0.63

− 3.1

(− 7.9, 1.7)

p = 0.2061

ES = 0.59

− 6.7

(− 11.5, − 1.9)

p = 0.0066

ES = 1.28

− 4.3

(− 9.2, 0.5)

p = 0.0802

ES = 0.83

25 mg HTL0018318

 MMTImm: Expl Error

2.6

(− 2.4, 7.5)

p = 0.3047

ES = 0.49

3.6

(− 1.4, 8.6)

p = 0.1565

ES = 0.69

1.4

(− 3.6, 6.4)

p = 0.5720

ES = 0.27

− 4.4

(− 9.3, 0.4)

p = 0.0718

ES = 0.84

− 7.7

(− 12.6, − 2.7)

p = 0.0025

ES = 1.46

− 4.8

(− 9.9, 0.3)

p = 0.0632

ES = 0.92

(20 + 35 mg) HTL0018318

 MMTImm: Expl Error

   

−8.9

(−15.7, − 2.1)

p = 0.0118

ES = 1.32

− 8.2

(− 15.0, − 1.4)

p = 0.0196

ES = 1.22

− 1.6

(− 8.4, 5.2)

p = 0.6317

ES = 0.24

  1. Mean estimated difference (95% CI), p-value, effect size