| Younger adults | Elderly | ||||
---|---|---|---|---|---|---|
Parameter | Day 1 | Day 5 | Day 10 | Day 1 | Day 5 | Day 10 |
15 mg HTL0018318 | ||||||
 MMTImm: Expl Error | − 1.2 (− 6.1, 3.7) p = 0.6303 ES = 0.23 | − 1.8 (− 6.7, 3.1) p = 0.4678 ES = 0.34 | − 2.6 (− 7.5, 2.4) p = 0.3050 ES = 0.49 | − 6.1 (− 10.8, − 1.3) p = 0.0133 ES = 1.15 | − 11.5 (− 16.3, − 6.7) p = <.0001 ES = 2.19 | − 7.0 (− 11.8, − 2.1) p = 0.0052 ES = 1.32 |
20 mg HTL0018318 | ||||||
 MMTImm: Expl Error | − 0.9 (− 5.9, 4.1) p = 0.7204 ES = 0.17 | − 0.4 (− 5.4, 4.6) p = 0.8637 ES = 0.08 | 3.3 (− 1.7, 8.3) p = 0.1930 ES = 0.63 | − 3.1 (− 7.9, 1.7) p = 0.2061 ES = 0.59 | − 6.7 (− 11.5, − 1.9) p = 0.0066 ES = 1.28 | − 4.3 (− 9.2, 0.5) p = 0.0802 ES = 0.83 |
25 mg HTL0018318 | ||||||
 MMTImm: Expl Error | 2.6 (− 2.4, 7.5) p = 0.3047 ES = 0.49 | 3.6 (− 1.4, 8.6) p = 0.1565 ES = 0.69 | 1.4 (− 3.6, 6.4) p = 0.5720 ES = 0.27 | − 4.4 (− 9.3, 0.4) p = 0.0718 ES = 0.84 | − 7.7 (− 12.6, − 2.7) p = 0.0025 ES = 1.46 | − 4.8 (− 9.9, 0.3) p = 0.0632 ES = 0.92 |
(20 + 35 mg) HTL0018318 | ||||||
 MMTImm: Expl Error |  |  |  | −8.9 (−15.7, − 2.1) p = 0.0118 ES = 1.32 | − 8.2 (− 15.0, − 1.4) p = 0.0196 ES = 1.22 | − 1.6 (− 8.4, 5.2) p = 0.6317 ES = 0.24 |