| Younger adults | Elderly | ||||
---|---|---|---|---|---|---|
Parameter | Day 1 | Day 5 | Day 10 | Day 1 | Day 5 | Day 10 |
15 mg HTL0018318 | ||||||
 N-back corr-incorr/total 2 | 0.079 (0.009, 0.148) p = 0.0265 ES = 1.06 | 0.074 (0.005, 0.143) p = 0.0361 ES = 1.00 | 0.102 (0.033, 0.172) p = 0.0041 ES = 1.38 | 0.074 (0.007, 0.142) p = 0.0318 ES = 1.00 | 0.008 (− 0.060, 0.076) p = 0.8070 ES = 0.11 | 0.036 (− 0.033, 0.105) p = 0.3016 ES = 0.49 |
20 mg HTL0018318 | ||||||
 N-back corr-incorr/total 2 | 0.070 (0.001, 0.140) p = 0.0476 ES = 0.95 | 0.059 (− 0.010, 0.129) p = 0.0947 ES = 0.80 | 0.081 (0.011, 0.151) p = 0.0237 ES = 1.09 | 0.145 (0.077, 0.213) p = <.0001 ES = 1.96 | 0.076 (0.008, 0.145) p = 0.0299 ES = 1.03 | 0.051 (− 0.019, 0.120) p = 0.1503 ES = 0.68 |
25 mg HTL0018318 | ||||||
 N-back corr-incorr/total 2 | 0.027 (− 0.042, 0.097) p = 0.4337 ES = 0.37 | 0.033 (− 0.038, 0.103) p = 0.3640 ES = 0.44 | 0.073 (0.002, 0.144) p = 0.0436 ES = 0.99 | 0.109 (0.041, 0.177) p = 0.0020 ES = 1.47 | 0.029 (− 0.042, 0.099) p = 0.4243 ES = 0.38 | 0.027 (− 0.047, 0.101) p = 0.4690 ES = 0.37 |
(20 + 35 mg) HTL0018318 | ||||||
 N-back corr-incorr/total 2 |  |  |  | 0.061 (− 0.030, 0.152) p = 0.1846 ES = 0.67 | 0.030 (− 0.062, 0.122) p = 0.5144 ES = 0.33 | 0.009 (− 0.083, 0.101) p = 0.8429 ES = 0.10 |