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Table 3 Effects on the accuracy of the 2-back performance compared with placebo

From: Safety, pharmacokinetics and exploratory pro-cognitive effects of HTL0018318, a selective M1 receptor agonist, in healthy younger adult and elderly subjects: a multiple ascending dose study

 

Younger adults

Elderly

Parameter

Day 1

Day 5

Day 10

Day 1

Day 5

Day 10

15 mg HTL0018318

 N-back corr-incorr/total 2

0.079

(0.009, 0.148)

p = 0.0265

ES = 1.06

0.074

(0.005, 0.143)

p = 0.0361

ES = 1.00

0.102

(0.033, 0.172)

p = 0.0041

ES = 1.38

0.074

(0.007, 0.142)

p = 0.0318

ES = 1.00

0.008

(− 0.060, 0.076)

p = 0.8070

ES = 0.11

0.036

(− 0.033, 0.105)

p = 0.3016

ES = 0.49

20 mg HTL0018318

 N-back corr-incorr/total 2

0.070

(0.001, 0.140)

p = 0.0476

ES = 0.95

0.059

(− 0.010, 0.129)

p = 0.0947

ES = 0.80

0.081

(0.011, 0.151)

p = 0.0237

ES = 1.09

0.145

(0.077, 0.213)

p = <.0001

ES = 1.96

0.076

(0.008, 0.145)

p = 0.0299

ES = 1.03

0.051

(− 0.019, 0.120)

p = 0.1503

ES = 0.68

25 mg HTL0018318

 N-back corr-incorr/total 2

0.027

(− 0.042, 0.097)

p = 0.4337

ES = 0.37

0.033

(− 0.038, 0.103)

p = 0.3640

ES = 0.44

0.073

(0.002, 0.144)

p = 0.0436

ES = 0.99

0.109

(0.041, 0.177)

p = 0.0020

ES = 1.47

0.029

(− 0.042, 0.099)

p = 0.4243

ES = 0.38

0.027

(− 0.047, 0.101)

p = 0.4690

ES = 0.37

(20 + 35 mg) HTL0018318

 N-back corr-incorr/total 2

   

0.061

(− 0.030, 0.152)

p = 0.1846

ES = 0.67

0.030

(− 0.062, 0.122)

p = 0.5144

ES = 0.33

0.009

(− 0.083, 0.101)

p = 0.8429

ES = 0.10

  1. Mean estimated difference (95% CI), p-value, effect size