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Table 3 Diagnostic accuracy of plasma Nfl and t-tau in the discrimination of CJD

From: Diagnostic and prognostic value of plasma neurofilament light and total-tau in sporadic Creutzfeldt-Jakob disease

 

Plasma Nfl

Plasma t-tau

CJD vs.

Cutoff

Sensitivity (%)

Specificity (%)

Cutoff

Sensitivity (%)

Specificity (%)

HC

> 33 pg/mL

100

100

> 6.0 pg/mL

84

100

Non-CJD-Dem

> 70 pg/mL

79

96

> 6.1 pg/mL

95

84

Non-CJD-neurodeg-Dem

> 70 pg/mL

88

96

> 6.1 pg/mL

95

84

  1. Sensitivity (in %), specificity (in %), and associated cutoff points (in pg/mL) for plasma Nfl and t-tau in the discrimination of CJD from HC, non-CJD-Dem, and non-CJD neurodeg-Dem