Fig. 4

Relation with disease stage and prognostic value of plasma Nfl and t-tau in CJD. Plasma Nfl (a) and t-tau (b) concentrations in CJD cases stratified in three categories according to whether blood was collected in the first stage/tertial (1st Ter, n = 17) (time of blood uptake to disease onset/total duration of the disease < 0.33), second stage/tertial (2nd Ter, n = 20) (0.33–0.66), or third stage/tertial (3rd Ter, n = 46) (> 0.66) of the disease. Plasma Nfl (c) and t-tau (d) in CJD cases classified as early stage (n = 51) and akinetic mutism (n = 31). Resultant significant corrected p values are displayed. Nfl, neurofilament light; t-tau, total-tau. d–f Association between disease duration (considered from disease onset and from blood uptake) and plasma Nfl and t-tau, measured with Spearman correlation coefficients (cc) and corresponding p values