Fig. 2

Plasma Nfl and t-tau in different AD subtypes and discrimination from CJD. Dot plot displaying a Nfl and b t-tau concentrations in HC (n = 70), NND (n = 26), spAD (n = 24), and rpAD (n = 16). Statistical significance derived from a comparative analysis corrected for covariates is indicated. Correlation analysis between plasma Nfl (c) and t-tau (d) concentrations with MMSE in AD cases. Correlation coefficients with 95% CI and associated p values derived from Spearmen test analysis are indicated. e AUC derived from ROC curves, with 95% CI in the comparative analysis of spAD and rpAD from CJD cases. p values derived from the comparative analysis of AUCs are indicated (corresponding statistical test is explained in Statistical analysis). AD, Alzheimer’s disease; spAD, slow progressive AD; rpAD, rapid progressive AD; Nfl, neurofilament light; t-tau, total-tau; AUC, area under the curve; ROC, receiver operating characteristic; 95% CI, 95% confidence interval