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Table 6 Analytes associated with latent factors

From: An integrative multi-omics approach reveals new central nervous system pathway alterations in Alzheimer’s disease

LF

Analyte

Full name

Entry#

Previously reported AD association

Proteomics

1

NRN1

Neuritin isoform 1 precursor

Q9NPD7

 

1

SMS

Spermine synthase

P52788

Yes [37]

1

NXPH4

Neurexophilin-4

O95158

 

1

LTBP1

Latent-transforming growth factor beta-binding protein 1

Q14766

 

1

CLUS

Clusterin

P10909

Yes [38]

1

NPDC1

Neural proliferation differentiation and control protein 1

Q9NQX5

 

1

PNOC

Prepronociceptin

Q13519

 

1

DYL2

Dynein light chain 2, cytoplasmic

Q96FJ2

 

1

PDGFB

Platelet-derived growth factor subunit B

P01127

Yes [39]

1

SAP3

Sphingolipid activator protein 3

P17900

 

1

MT1E

Metallothionein-1E

P04732

Yes [40]

1

PCSK1

Neuroendocrine convertase 1

P29120

Yes [41]

1

TAGL

Transgelin-2

P37802

Yes [42]

1

MT3

Metallothionein-3

P25713

Yes [40]

1

LY6H

Lymphocyte antigen 6H

O94772

 

2

SAMP

Spindle-associated membrane protein 1

Q5SNT2

 

2

VTNC

Vitronectin

P04004

Yes [43]

2

KNG1

Kininogen-1

P01042

 

2

FETUA

Alpha-2-HS-glycoprotein

P02765

Yes [44]

2

HELZ

Probable helicase with zinc finger domain

P42694

 

2

PLMN

Plasminogen

P00747

Yes [45]

2

PGRP2

N-acetylmuramoyl-L-alanine amidase

Q96PD5

 

2

AFAM

Afamin

P43652

Yes [44]

2

ITIH1

Inter-alpha-trypsin inhibitor heavy chain H1

P19827

Yes [46]

2

CO8B

Complement component C8 beta chain

P07358

Yes [47]

2

FIBA

Fibrinogen alpha chain

P02671

Yes [48]

2

CO6

Complement component C6

P13671

Yes [47]

2

ITIH4

Inter-alpha-trypsin inhibitor heavy chain H4

Q14624

Yes [46]

3

EPDR1

Mammalian ependymin-related protein 1

Q9UM22

 

3

SIAE

Sialate O-acetylesterase

Q9HAT2

 

4

X1433Z

14-3-3 protein zeta/delta

P63104

Yes [49]

4

S10A6

Protein S100-A6

P06703

Yes [50]

4

PRDX6

Peroxiredoxin-6

P30041

Yes [51]

5

VTM2A

V-set and transmembrane domain-containing protein 2A

Q8TAG5

 

5

S10A6

Protein S100-A6

P06703

Yes [50]

5

CMGA

Chromogranin-A

P10645

Yes [52]

5

ZP2

Zona pellucida sperm-binding protein 2

Q05996

 

5

SLIK1

SLIT and NTRK-like protein 1

Q96PX8

Yes [53]

Neuroinflammation

1

sVCAM-1

Circulating vascular cell adhesion molecule-1

P19320

Yes [54]

1

IL-15

Interleukin-15

P40933

Yes [54]

1

sICAM-1

Soluble intracellular adhesion molecule-1

P05362

Yes [54]

2

SAA

Serum amyloid A

P0DJI8

Yes [55]

2

PIGF_1R

Insulin-like growth factor 1 receptor

P08069

Yes [56]

3

PIGF_1R

Insulin-like growth factor 1 receptor

P08069

Yes [56]

4

IL-16

Interleukin-16

Q14005

Yes [57]

5

MCP-1

Monocyte chemoattractant protein-1

P13500

Yes [54]

5

PIGF_1R

Insulin-like growth factor 1 receptor

P08069

Yes [56]

One-carbon metabolism

1

MTHF

5-methyltetrahydrofolate

20,612

Yes [58]

1

SAH

S-adenosyl-L-homocysteine

16,680

Yes [59]

2

CYST

Total cysteine

15,356

Yes [60]

3

SAH

S-adenosyl-L-homocysteine

16,680

Yes [59]

4

CYST

Total cysteine

15,356

Yes [60]

5

CYST

Total cysteine

15,356

Yes [60]

Metabolomics

1

N/A

Glycoproteins

17,089

Yes [61]

2

N/A

Alanine

16,449

Yes [62]

2

N/A

Valine

27,266

 

2

N/A

Glycoproteins

17,089

Yes [61]

3

N/A

Inositol

24,848

 

4

N/A

Glycoproteins

17,089

Yes [61]

5

N/A

Formic acid

30,751

 

5

S69

Unidentified metabolite

N/A

N/A

5

N/A

Acetoacetic acid

15,344

Yes [63]

Lipidomics

1

PC 32:0

1,2-Dihexadecanoyl-sn-glycero-3-phosphocholine

N/A

Yes [64]

2

SE 27:1 18:2

Cholesteryl ester

N/A

 

3

PC 32:0

1,2-Dihexadecanoyl-sn-glycero-3-phosphocholine

N/A

Yes [64]

4

SE 27:1 18:2

Cholesteryl ester

N/A

 

4

SE 27:1 20:4

Cholesteryl ester

N/A

 

4

SE 27:1 16:0

Cholesteryl ester

N/A

 

5

LPG 20:1

1-(11Z-eicosenoyl)-glycero-3-phospho-(1′-sn-glycerol)

N/A

 
  1. CSF biomolecules significantly associated with the LFs within the MOFA model and whether they have been previously associated with AD. Entry# denotes the analyte identifier within the UniProt database (for proteomics and neuroinflammation) or ChEBI database (for other analytes)