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Table 4 Analytes associated with CSF Tau

From: An integrative multi-omics approach reveals new central nervous system pathway alterations in Alzheimer’s disease

 

Coeff.

Lipidomics

 DAG 34:0

1080.894

 PC 32:0

482.8502

 PC 34:1

357.532

 LPA 16:0

117.3799

 SE 27:1 18:3

− 15.4237

 SE 27:1 18:2

− 22.0295

Metabolomics

 Glycoproteins

519.5138

 3-Hydroxyisovaleric acid

154.6212

 Hydroxybutyric acid

71.2998

 S56

− 5.1297

 S62

− 49.1323

 Glucose

− 134.352

One-carbon metabolism

 S-adenosylhomocysteine

264.4874

 Choline

15.9208

 5-Methyltetrahydrofolate

− 361.534

Neuroinflammation

 Soluble fms-like tyrosine kinase 1

473.9178

 Il-15

173.1296

 Soluble vascular cell adhesion molecule-1

159.6389

 Soluble intracellular cell adhesion molecule-1

90.9487

 Monocyte chemoattractant protein-1

41.9127

Proteomics

 14-3-3 protein zeta/delta

283.67

 brain abundant membrane attached signal protein 1

107.72

 SPARC related modular calcium binding protein 1

64.03

 Neuromodulin

55.50

 Fructose-biphosphate aldolase A

52.77

 Neurofilament medium polypeptide

49.02

 Transgelin-3

31.42

 Secreted-frizzled-related protein 4

− 1.86

 Chondroadherin

− 7.99

 Dynein heavy chain 10, axonemal

− 11.34

 Glia-derived nexin

− 13.09

 A-kinase anchor protein 11

− 18.52

 Reelin

− 18.86

 Augurin

− 43.98

 Spectrin beta chain, non-erythrocytic 1

− 52.34

 Sialate O-acetylesterase

− 56.71

 Proline-rich acidic protein 1

− 80.54

 Fibromodulin

− 84.41

 Cathepsin D

− 144.10

 Insulin-like growth factor-binding protein 7

− 169.27

 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2

− 213.32

  1. Analytes within the whole cohort with a significant association with CSF Tau sorted by decreasing absolute association strength within each modality. For each analyte, the coefficient obtained by Elastic-Net regression is shown. S56 and S62 represent different unidentified metabolites