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Table 3 Mean values of AD CSF biomarkers, gravity drip versus aspiration extraction method

From: Core Alzheimer’s disease cerebrospinal fluid biomarker assays are not affected by aspiration or gravity drip extraction methods

  All participants N = 50 Cognitively normal N = 36 Mild cognitive impairment N = 8 Alzheimer’s disease N = 6
Mean (SD)   Mean (SD)   Mean (SD)   Mean (SD)  
Aspiration Gravity p value Aspiration Gravity p value Aspiration Gravity p value Aspiration Gravity p value
α-synuclein 2370 (861) 2370 (866) 1.00 2330 (850) 2330 (866) 1.00 2370 (607) 2430 (594) 0.85 2570 (1280) 2530 (1240) 0.95
Neurogranin 356 (162) 371 (174) 0.73 331 (166) 343 (174) 0.77 400 (126) 425 (161) 0.73 446 (154) 466 (158) 0.83
Aβ42 535 (265) 550 (274) 0.88 603 (242) 617 (244) 0.81 405 (263) 416 (274) 0.94 298 (229) 327 (309) 0.86
Aβ40 7570 (2400) 7850 (2800) 0.78 7840 (2510) 8120 (2940) 0.66 7670 (1990) 7900 (2460) 0.84 5820 (1580) 6140 (1940) 0.76
BACE1 2250 (841) 2260 (813) 0.95 2240 (783) 2240 (765) 0.96 2260 (525) 2270 (571) 0.99 2300 (1500) 2370 (1380) 0.93
Tau 450 (176) 456 (181) 0.90 397 (138) 399 (137) 0.96 552 (214) 558 (221) 0.96 634 (166) 666 (165) 0.75
Aβ42/Aβ40 0.069 (0.026) 0.070 (0.028) 0.98 0.076 (0.023) 0.077 (0.025) 0.87 0.051 (0.022) 0.052 (0.025) 0.91 0.047 (0.025) 0.047 (0.030) 0.98
Ratio/Tau* 1.97 (1.30) 2.00 (1.37) 0.93 2.34 (1.29) 2.38 (1.36) 0.90 1.15 (0.79) 1.21 (0.92) 0.89 0.82 (0.58) 0.75 (0.55) 0.83
Aβ42/Tau 1.39 (0.79) 1.42 (0.82) 0.96 1.64 (0.69) 1.67 (0.71) 0.84 0.92 (0.81) 0.93 (0.81) 0.99 0.51 (0.48) 0.53 (0.57) 0.96
  1. Abbreviations: amyloid beta, AD Alzheimer’s disease, CSF cerebrospinal fluid, SD standard deviation, tTau total tau, N number of participants. All biomarker values are expressed in pg/mL. * Ratio; Aβ42/40