Table 3 Mean values of AD CSF biomarkers, gravity drip versus aspiration extraction method
All participants N = 50 | Cognitively normal N = 36 | Mild cognitive impairment N = 8 | Alzheimer’s disease N = 6 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | |||||||||
Aspiration | Gravity | p value | Aspiration | Gravity | p value | Aspiration | Gravity | p value | Aspiration | Gravity | p value | |
α-synuclein | 2370 (861) | 2370 (866) | 1.00 | 2330 (850) | 2330 (866) | 1.00 | 2370 (607) | 2430 (594) | 0.85 | 2570 (1280) | 2530 (1240) | 0.95 |
Neurogranin | 356 (162) | 371 (174) | 0.73 | 331 (166) | 343 (174) | 0.77 | 400 (126) | 425 (161) | 0.73 | 446 (154) | 466 (158) | 0.83 |
Aβ42 | 535 (265) | 550 (274) | 0.88 | 603 (242) | 617 (244) | 0.81 | 405 (263) | 416 (274) | 0.94 | 298 (229) | 327 (309) | 0.86 |
Aβ40 | 7570 (2400) | 7850 (2800) | 0.78 | 7840 (2510) | 8120 (2940) | 0.66 | 7670 (1990) | 7900 (2460) | 0.84 | 5820 (1580) | 6140 (1940) | 0.76 |
BACE1 | 2250 (841) | 2260 (813) | 0.95 | 2240 (783) | 2240 (765) | 0.96 | 2260 (525) | 2270 (571) | 0.99 | 2300 (1500) | 2370 (1380) | 0.93 |
Tau | 450 (176) | 456 (181) | 0.90 | 397 (138) | 399 (137) | 0.96 | 552 (214) | 558 (221) | 0.96 | 634 (166) | 666 (165) | 0.75 |
Aβ42/Aβ40 | 0.069 (0.026) | 0.070 (0.028) | 0.98 | 0.076 (0.023) | 0.077 (0.025) | 0.87 | 0.051 (0.022) | 0.052 (0.025) | 0.91 | 0.047 (0.025) | 0.047 (0.030) | 0.98 |
Ratio/Tau* | 1.97 (1.30) | 2.00 (1.37) | 0.93 | 2.34 (1.29) | 2.38 (1.36) | 0.90 | 1.15 (0.79) | 1.21 (0.92) | 0.89 | 0.82 (0.58) | 0.75 (0.55) | 0.83 |
Aβ42/Tau | 1.39 (0.79) | 1.42 (0.82) | 0.96 | 1.64 (0.69) | 1.67 (0.71) | 0.84 | 0.92 (0.81) | 0.93 (0.81) | 0.99 | 0.51 (0.48) | 0.53 (0.57) | 0.96 |