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Table 2 Brain regions with significant differences between SCD and NC based on voxel analysis

From: Glucose metabolism in the right middle temporal gyrus could be a potential biomarker for subjective cognitive decline: a study of a Han population

MNI coordinate (mm) Cluster location (AAL template) Hemisphere Cluster size Metabolic change from SCD to NC
X Y Z
50 − 60 24 Temporal_Mid; Angular; Temporal_Sup Right 573 Hypometabolism
60 − 26 16 Temporal_Sup; SupraMarginal; Postcentral; Precentral Right 492 Hypometabolism
30 − 46 − 42 Fusiform; ParaHippocampal; Temporal_Pole_Mid; Temporal_Inf Right 332 Hypometabolism
54 − 40 34 SupraMarginal; Parietal_Inf; Temporal_Sup; Temporal_Mid Right 297 Hypometabolism
− 24 54 − 12 Frontal_Sup_Orb; Frontal_Mid_Orb; Rectus; Frontal_Med_Orb Left 262 Hypometabolism
− 40 8 − 38 Temporal_Inf; Temporal_Pole_Mid; Temporal_Pole_Sup; Fusiform Left 257 Hypometabolism
24 − 48 − 6 Lingual; Fusiform Right 216 Hypometabolism
18 − 36 − 20 Frontal_Sup_Orb; Frontal_Mid_Orb; Frontal_Med_Orb Right 188 Hypometabolism
− 20 − 14 − 14 Hippocampus; Amygdala; Left 162 Hypometabolism
52 − 4 − 34 Temporal_Inf; Temporal_Mid Right 153 Hypometabolism
62 − 10 −18 Temporal_Mid; Temporal_Sup Right 146 Hypometabolism
− 62 − 14 − 14 Temporal_Mid Left 144 Hypometabolism
4 − 94 8 Calcarine; Cuneus; Occipital_Mid Left, right 505, 166 Hypermetabolism
− 20 − 86 34 Occipital_Sup; Cuneus; Occipital_Mid Left 371 Hypermetabolism
− 20 − 74 52 Parietal_Sup; Precuneus; Parietal_Inf Left 210 Hypermetabolism
4 24 44 Frontal_Sup_Medial; Supp_Motor_Area Left, right 90, 111 Hypermetabolism
28 52 − 10 Frontal_Mid_Orb; Frontal_Inf_Orb Right 159 Hypermetabolism
44 16 2 Insula; Frontal_Inf_Oper Right 153 Hypermetabolism
− 4 50 16 Frontal_Sup_Medial; Cingulum_Ant Left 138 Hypermetabolism
4 − 62 66 Precuneus Left; right 64, 52 Hypermetabolism
18 − 68 58 Parietal_Sup Right 114 Hypermetabolism
  1. Voxel analysis between NC (NC1 + NC2) and SCD (SCD1 + SCD2). The threshold of the t-map was set to p < 0.05, cluster size > 100
  2. Abbreviations: MNI Montreal Neurological Institute, AAL anatomical automatic labeling, SCD subjective cognitive decline, NC normal control, mid middle, sup superior, inf inferior, orb orbital, ant anterior