| |
Cohort 1 (n = 58)
|
Cohort 2 (n = 145)
|
|---|
|
NC1 (26)
|
SCD1 (32)
|
NC2 (36)
|
SCD2 (23)
|
aMCI (32)
|
ADD (32)
|
DLB (22)
|
|---|
|
Female, n (%)
|
13 (50.0%)
|
25 (78.1%)*
|
23 (63.9%)
|
21 (91.3%)
|
14(43.8%)
|
13(40.6%)
|
1(4.5%)††
|
|
Age
|
66.38 ± 4.51
|
66.00 ± 4.83
|
65.16 ± 4.26
|
65.82 ± 4.28
|
67.81 ± 6.99
|
60.66 ± 8.87
|
66.91 ± 8.41††
|
|
Education
|
13.42 ± 2.88
|
13.18 ± 2.64
|
12.68 ± 2.86
|
13.04 ± 2.73
|
13.03 ± 3.02
|
13.10 ± 4.15
|
13.05 ± 3.65
|
|
APOE ε4, n (%)
|
9 (34.6%)
|
7 (21.9%)
|
7 (19.4%)
|
6 (26.1%)
|
N/A
|
N/A
|
N/A
|
|
MMSE
|
29.34 ± 0.79
|
29.12 ± 0.90
|
29.22 ± 0.92
|
29.00 ± 0.67
|
25.53 ± 3.45
|
19.09 ± 5.77
|
20.05 ± 4.99††
|
|
MoCA-B
|
26.00 ± 1.87
|
26.75 ± 1.70
|
26.63 ± 2.05
|
26.04 ± 1.63
|
22.66 ± 1.73
|
N/A
|
N/A
|
|
SCD-9
|
2.98 ± 2.25
|
5.29 ± 1.92**
|
3.23 ± 1.79
|
5.06 ± 1.50**
|
5.59 ± 1.32
|
N/A
|
N/A
|
|
HAMD
|
2.34 ± 2.63
|
3.37 ± 3.12
|
1.41 ± 1.66
|
4.00 ± 3.95*
|
2.38 ± 1.52
|
N/A
|
N/A
|
|
HAMA
|
2.96 ± 2.44
|
4.46 ± 3.27
|
2.91 ± 2.83
|
5.34 ± 3.74*
|
2.56 ± 1.68
|
N/A
|
N/A
|
|
AVLT-N5
|
7.67 ± 1.89
|
7.34 ± 1.67
|
7.65 ± 2.03
|
7.81 ± 1.87
|
4.01 ± 1.67
|
N/A
|
N/A
|
|
AVLT-N7
|
22.46 ± 1.42
|
22.65 ± 1.38
|
22.50 ± 1.44
|
22.52 ± 1.75
|
16.73 ± 2.58
|
N/A
|
N/A
|
- Categorical and continuous measures are presented as numbers (%) or as means ± standard deviations. Statistical analyses were conducted by chi-square tests for categorical variables, independent two-sample two-tailed t-tests (MoCA-B, SCD-9, HAMD, HAMA, AVLT-N5, and AVLT-N7 in cohorts 1 and 2) or one-way ANOVA followed by post hoc tests (education, MMSE in cohort 2) for continuous variables. Comparisons between the two groups, * means p < 0.05, ** means p < 0.001; comparisons among the five groups, †† means p < 0.001, results of the post hoc tests were not marked; the neuropsychological scales of MoCA-B, SCD-9, HAMD, HAMA, AVLT-N5, and AVLT-N7 were not compared among the three groups of NC2, SCD2, and aMCI
- Abbreviations: NC normal control, SCD subjective cognitive decline, aMCI amnestic mild cognitive impairment, ADD AD-dementia, DLB dementia with Lewy body, APOE apolipoprotein E, MMSE Mini-Mental State Examination, MoCA-B Montreal cognitive assessment-basic, SCD-9 Subjective Cognitive Decline-9, HAMD Hamilton depression scale, HAMA Hamilton anxiety scale, AVLT-N5 Auditory verbal learning test-long delayed memory, AVLT-N7 Auditory verbal learning test-recognition, ANOVA analysis of variance, N/A not applicable
