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Table 1 Clinical characteristics of the participants

From: Glucose metabolism in the right middle temporal gyrus could be a potential biomarker for subjective cognitive decline: a study of a Han population

  Cohort 1 (n = 58) Cohort 2 (n = 145)
NC1 (26) SCD1 (32) NC2 (36) SCD2 (23) aMCI (32) ADD (32) DLB (22)
Female, n (%) 13 (50.0%) 25 (78.1%)* 23 (63.9%) 21 (91.3%) 14(43.8%) 13(40.6%) 1(4.5%)††
Age 66.38 ± 4.51 66.00 ± 4.83 65.16 ± 4.26 65.82 ± 4.28 67.81 ± 6.99 60.66 ± 8.87 66.91 ± 8.41††
Education 13.42 ± 2.88 13.18 ± 2.64 12.68 ± 2.86 13.04 ± 2.73 13.03 ± 3.02 13.10 ± 4.15 13.05 ± 3.65
APOE ε4, n (%) 9 (34.6%) 7 (21.9%) 7 (19.4%) 6 (26.1%) N/A N/A N/A
MMSE 29.34 ± 0.79 29.12 ± 0.90 29.22 ± 0.92 29.00 ± 0.67 25.53 ± 3.45 19.09 ± 5.77 20.05 ± 4.99††
MoCA-B 26.00 ± 1.87 26.75 ± 1.70 26.63 ± 2.05 26.04 ± 1.63 22.66 ± 1.73 N/A N/A
SCD-9 2.98 ± 2.25 5.29 ± 1.92** 3.23 ± 1.79 5.06 ± 1.50** 5.59 ± 1.32 N/A N/A
HAMD 2.34 ± 2.63 3.37 ± 3.12 1.41 ± 1.66 4.00 ± 3.95* 2.38 ± 1.52 N/A N/A
HAMA 2.96 ± 2.44 4.46 ± 3.27 2.91 ± 2.83 5.34 ± 3.74* 2.56 ± 1.68 N/A N/A
AVLT-N5 7.67 ± 1.89 7.34 ± 1.67 7.65 ± 2.03 7.81 ± 1.87 4.01 ± 1.67 N/A N/A
AVLT-N7 22.46 ± 1.42 22.65 ± 1.38 22.50 ± 1.44 22.52 ± 1.75 16.73 ± 2.58 N/A N/A
  1. Categorical and continuous measures are presented as numbers (%) or as means ± standard deviations. Statistical analyses were conducted by chi-square tests for categorical variables, independent two-sample two-tailed t-tests (MoCA-B, SCD-9, HAMD, HAMA, AVLT-N5, and AVLT-N7 in cohorts 1 and 2) or one-way ANOVA followed by post hoc tests (education, MMSE in cohort 2) for continuous variables. Comparisons between the two groups, * means p < 0.05, ** means p < 0.001; comparisons among the five groups, †† means p < 0.001, results of the post hoc tests were not marked; the neuropsychological scales of MoCA-B, SCD-9, HAMD, HAMA, AVLT-N5, and AVLT-N7 were not compared among the three groups of NC2, SCD2, and aMCI
  2. Abbreviations: NC normal control, SCD subjective cognitive decline, aMCI amnestic mild cognitive impairment, ADD AD-dementia, DLB dementia with Lewy body, APOE apolipoprotein E, MMSE Mini-Mental State Examination, MoCA-B Montreal cognitive assessment-basic, SCD-9 Subjective Cognitive Decline-9, HAMD Hamilton depression scale, HAMA Hamilton anxiety scale, AVLT-N5 Auditory verbal learning test-long delayed memory, AVLT-N7 Auditory verbal learning test-recognition, ANOVA analysis of variance, N/A not applicable