Fig. 1

The results of SCD glucose metabolic biomarkers based on ROI analysis. In the metabolic comparisons between SCD patients and NCs, this study considered the 90 regions (AAL template) as ROIs and calculated the mean SUVR value of each ROI, which was adjusted for age, sex, and education. Permutation tests 1000 times were used to find significant differences between NC1 and SCD1 as well as between NC2 and SCD2. a and b show the SCD regional changes of 90 ROIs compared with NC, where a NC1 and SCD1 were used from cohort 1, b NC2 and SCD2 were used from cohort 2, and c shows the intersection areas of significantly different regions in (a) and (b). The regions with metabolic changes of SCD are overlaid on the structural MRI template images. Cool colors represent voxels with negative region weights and hypometabolism, and hot colors represent voxels with positive weights and hypermetabolism. Abbreviations: SCD, subjective cognitive decline; ROI, region of interest; NC, normal control; AAL, anatomical automatic labeling; SUVR, standardized uptake value ratio; MRI, magnetic resonance imaging