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Fig. 6 | Alzheimer's Research & Therapy

Fig. 6

From: Comorbidity between Alzheimer’s disease and major depression: a behavioural and transcriptomic characterization study in mice

Fig. 6

Comparison of differentially expressed gene sets in APP/PSEN1-Tg mice in the PFC, striatum, hippocampus and amygdala. a The heatmap represents some selected up- and downregulated gene sets at 3 and 6 months old included in different biological processes: Alzheimer disease, depressive disorders, memory impairment, prion disease, motor impairment (Motor imp.), neurodegeneration, neuroinflammation, neuroplasticity, neurotransmission (Neurotrans.), cell adhesion, circadian rhythm and electron transport chain (ETC) (FDR q value < 0.05; |normalized enrichment score| > 1.4.). List of the total number of differentially expressed gene sets ordered by biological processes found in the PFC (b, f), striatum (c, g), hippocampus (d, g) and amygdala (e, j) at 3 and 6 months old, respectively. Red bars (positive) represent the upregulated expressed gene sets and the blue bars (negative) show downregulated gene sets in each area. For the GSEA, we only included those gene sets with FDR q value < 0.05 and |NES| > 1.4

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