Fig. 3

APP/PSEN1-Tg mice show olfaction disruptions at 6 months old. Graphs show the time (centiseconds, cs) that APP/PSEN1-Tg and non-transgenic animals spent investigating a cotton swab through consecutive 1-min presentations (mean ± SEM) of distilled water (presentations 1–6 and 8–12) and limonene (presentation 7) at 3 (a) and 6 months (c). The exploration time during the first presentation of the cotton swab with water [1] was compared with that of the first presentation of limonene [7] in each group (Wilcoxon test, **p < 0.01 comparison of APP/PSEN1-Tg water vs limonene presentations; ⁺⁺p < 0.01 comparison of non-transgenic water vs limonene presentations; Kruskal–Wallis test ^$p < 0.05 comparison of APP/PSEN1-Tg vs Non-Transgenic). Grey (non-transgenic) and yellow (APP/PSEN1-Tg) bars represent the total investigation time at 3 (b) (n = 12 per group) and 6 (d) months old (non-transgenic n = 11, APP/PSEN1-Tg n = 12) (Student’s t-test *p < 0.05). Data are presented as mean ± SEM