From: A novel age-informed approach for genetic association analysis in Alzheimer’s disease
Sample | N (% females) | Age μ (σ) | ε3/ε3 (%) | ε3/ε4 (%) | ε4/ε4 (%) | ε2/ε3 (%) | ε2/ε4 (%) | ε2/ε2 (%) |
---|---|---|---|---|---|---|---|---|
Discovery – (WES + WGS) | ||||||||
Controls | 5075 (59.0) | 85.2 (5.4) | 66.13 | 13.93 | 0.51 | 17.12 | 1.52 | 0.79 |
AD cases | 6052 (57.8) | 76.3 (8.2) | 47.54 | 39.29 | 4.23 | 6.08 | 2.46 | 0.4 |
Replication – (imputed SNP arrays) | ||||||||
Controls | 10,539 (59.4) | 76.7 (8.5) | 60.98 | 22.01 | 2.07 | 12.11 | 2.18 | 0.65 |
AD cases | 11,092 (60.5) | 73.3 (9.3) | 32.83 | 44.37 | 16.21 | 3.69 | 2.79 | 0.1 |