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Table 1 Detailed demographics for discovery and replication sample. Details per cohort included in the discovery and replication can be found respectively in Tables S1 and S2. HC healthy controls, AD Alzheimer’s disease

From: A novel age-informed approach for genetic association analysis in Alzheimer’s disease

Sample

N

(% females)

Age

μ (σ)

ε3/ε3

(%)

ε3/ε4

(%)

ε4/ε4

(%)

ε2/ε3

(%)

ε2/ε4

(%)

ε2/ε2

(%)

Discovery – (WES + WGS)

 Controls

5075 (59.0)

85.2 (5.4)

66.13

13.93

0.51

17.12

1.52

0.79

 AD cases

6052 (57.8)

76.3 (8.2)

47.54

39.29

4.23

6.08

2.46

0.4

Replication – (imputed SNP arrays)

 Controls

10,539 (59.4)

76.7 (8.5)

60.98

22.01

2.07

12.11

2.18

0.65

 AD cases

11,092 (60.5)

73.3 (9.3)

32.83

44.37

16.21

3.69

2.79

0.1