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Table 6 Regional 18F-flortaucipir SUVRs by amyloid group (n = 270, dataset #5)

From: Early detection of amyloid load using 18F-florbetaben PET

  

18F-Flortaucipir SUVR

Method

Region

Aβ-negative

Gray zone

Established Aβ pathology

MRI-based ROI

Mesial temporal

1.16 ± 0.09

1.18 ± 0.10 (p = 0.51)

1.32 ± 0.15 (p < 10−5)

Fusiform gyrus

1.15 ± 0.09

1.16 ± 0.08 (p = 0.91)

1.34 ± 0.24 (p < 10−5)

Inferior temporal

1.15 ± 0.10

1.17 ± 0.10 (p = 0.87)

1.32 ± 0.15 (p < 10−5)

Parietal

1.03 ± 0.07

1.05 ± 0.07 (p = 0.58)

1.15 ± 0.23 (p < 10−5)

CL

Mesial temporal

1.16 ± 0.09

1.18 ± 0.11 (p = 0.45)

1.33 ± 0.15 (p < 10−5)

Fusiform gyrus

1.15 ± 0.08

1.16 ± 0.09 (p = 0.88)

1.35 ± 0.24 (p < 10−5)

Inferior temporal

1.15 ± 0.05

1.18 ± 0.11(p = 0.60)

1.38 ± 0.28 (p < 10−5)

Parietal

1.03 ± 0.06

1.06 ± 0.09 (p = 0.37)

1.16 ± 0.24 (p < 10−5)

  1. SUVR 18F-flortaucipir SUVRs (mean ± SD), amyloid-beta, MRI magnetic resonance imaging, MRI magnetic resonance imaging, ROI region of interest, CL centiloid. p-values using ANOVA to test whether 18F-flortaucipir SUVRs in each group are significantly larger than in Aβ-negative subjects are given in parenthesis