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Table 6 Regional 18F-flortaucipir SUVRs by amyloid group (n = 270, dataset #5)

From: Early detection of amyloid load using 18F-florbetaben PET

   18F-Flortaucipir SUVR
Method Region Aβ-negative Gray zone Established Aβ pathology
MRI-based ROI Mesial temporal 1.16 ± 0.09 1.18 ± 0.10 (p = 0.51) 1.32 ± 0.15 (p < 10−5)
Fusiform gyrus 1.15 ± 0.09 1.16 ± 0.08 (p = 0.91) 1.34 ± 0.24 (p < 10−5)
Inferior temporal 1.15 ± 0.10 1.17 ± 0.10 (p = 0.87) 1.32 ± 0.15 (p < 10−5)
Parietal 1.03 ± 0.07 1.05 ± 0.07 (p = 0.58) 1.15 ± 0.23 (p < 10−5)
CL Mesial temporal 1.16 ± 0.09 1.18 ± 0.11 (p = 0.45) 1.33 ± 0.15 (p < 10−5)
Fusiform gyrus 1.15 ± 0.08 1.16 ± 0.09 (p = 0.88) 1.35 ± 0.24 (p < 10−5)
Inferior temporal 1.15 ± 0.05 1.18 ± 0.11(p = 0.60) 1.38 ± 0.28 (p < 10−5)
Parietal 1.03 ± 0.06 1.06 ± 0.09 (p = 0.37) 1.16 ± 0.24 (p < 10−5)
  1. SUVR 18F-flortaucipir SUVRs (mean ± SD), amyloid-beta, MRI magnetic resonance imaging, MRI magnetic resonance imaging, ROI region of interest, CL centiloid. p-values using ANOVA to test whether 18F-flortaucipir SUVRs in each group are significantly larger than in Aβ-negative subjects are given in parenthesis