From: Early detection of amyloid load using 18F-florbetaben PET
Percent Aβ deposition per year | ||||
---|---|---|---|---|
Method | Region | Aβ-negative | Gray zone | Established Aβ pathology |
MRI-based ROIs | Frontal | − 0.49 ± 2.52 (p = 0.73) | 0.85 ± 2.20 (p = 0.19) | 1.37 ± 2.02 (p = 0.002) |
Lateral temporal | 0.15 ± 1.83 (p = 0.40) | 0.88 ± 1.58 (p = 0.08) | 1.66 ± 1.90 (p < 10−3) | |
Occipital | 0.30 ± 1.64 (p = 0.21) | 0.24 ± 1.78 (p = 0.44) | 0.94 ± 2.28 (p = 0.055) | |
Parietal | − 0.48 ± 1.72 (p = 0.87) | 1.39 ± 1.23 (p = 0.09) | 1.12 ± 1.88 (p = 0.009) | |
Anterior cingulate | − 0.79 ± 2.49 (p = 0.87) | 0.97 ± 0.22 (p = 0.01) | 0.76 ± 2.51 (p = 0.08) | |
Posterior cingulate | 0.71 ± 1.41 (p = 0.04) | N.A | 1.58 ± 2.26 (p = 0.001) | |
Precuneus | 0.01 ± 1.37 (p = 0.49) | 1.24 ± 1.56 (p = 0.11) | 1.44 ± 2.31 (p = 0.004) | |
Composite | − 0.29 ± 1.68 (p = 0.74) | 1.51 ± 1.38 (p = 0.04) | 1.23 ± 1.90 (p = 0.004) | |
CL | Cortex | 0.08 ± 1.62 (p = 0.43) | 2.62 ± 1.47 (p = 0.045) | 1.41 ± 1.82 (p = 0.001) |