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Table 5 Regional percent of Aβ deposition per year in a sample of MCI subjects (n = 44, dataset #4)

From: Early detection of amyloid load using 18F-florbetaben PET

   Percent Aβ deposition per year
Method Region Aβ-negative Gray zone Established Aβ pathology
MRI-based ROIs Frontal − 0.49 ± 2.52 (p = 0.73) 0.85 ± 2.20 (p = 0.19) 1.37 ± 2.02 (p = 0.002)
Lateral temporal 0.15 ± 1.83 (p = 0.40) 0.88 ± 1.58 (p = 0.08) 1.66 ± 1.90 (p < 10−3)
Occipital 0.30 ± 1.64 (p = 0.21) 0.24 ± 1.78 (p = 0.44) 0.94 ± 2.28 (p = 0.055)
Parietal − 0.48 ± 1.72 (p = 0.87) 1.39 ± 1.23 (p = 0.09) 1.12 ± 1.88 (p = 0.009)
Anterior cingulate − 0.79 ± 2.49 (p = 0.87) 0.97 ± 0.22 (p = 0.01) 0.76 ± 2.51 (p = 0.08)
Posterior cingulate 0.71 ± 1.41 (p = 0.04) N.A 1.58 ± 2.26 (p = 0.001)
Precuneus 0.01 ± 1.37 (p = 0.49) 1.24 ± 1.56 (p = 0.11) 1.44 ± 2.31 (p = 0.004)
Composite − 0.29 ± 1.68 (p = 0.74) 1.51 ± 1.38 (p = 0.04) 1.23 ± 1.90 (p = 0.004)
CL Cortex 0.08 ± 1.62 (p = 0.43) 2.62 ± 1.47 (p = 0.045) 1.41 ± 1.82 (p = 0.001)
  1. MCI mild cognitive impairment, N.A not available (As Aβ-negative, gray zone, and established Aβ pathology were defined regionally using cutoffs reported in Tables 2 and 3, there were not enough regional standardized uptake values (SUVRs) to calculate percent Aβ deposition per year in some regions), amyloid-beta, MRI magnetic resonance imaging, ROI region of interest, CL centiloid. p-values testing whether percent Aβ deposition per year is significantly larger than zero are given in parenthesis