Fig. 4

Histograms of composite standardized uptake value ratios (SUVRs) and centiloids (CLs) for the sample of subjective cognitive decline (SCD) (n = 168, dataset #3) subjects at baseline (first column) and at follow-up (central column). Red and blue lines represent the SUVR abnormality cutoffs for early Aβ detection and established Aβ pathology, respectively. The rate of Aβ accumulation in SCD (and 95% confidence interval in red) in three categories of the composite SUVR continuum (Aβ-negative, gray zone, and established Aβ deposition) is shown on the right column. ROI region of interest