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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Plasma neurofilament light and phosphorylated tau 181 as biomarkers of Alzheimer’s disease pathology and clinical disease progression

Fig. 2

Models for the prediction of AD. a-b Binomial logistic regression models with the presence of AD pathology as dependent variable along with sex, age, years of education, APOE ε4 carrier status, plasma NfL and plasma p-tau181 levels, with no variable selection (a) or backwards variable selection (b). Coefficients (B) and odds-ratio (Exp(B)) are shown. c ROC curves from predictive models of the presence of AD in CI participants. The reference model (blue) and the reference model with p-tau-181 levels (red) are shown. The 0.5 AUC reference line is shown in green. ROC curves for CN participants for either models are not shown. d AUC of ROC curves obtained by the reference model (Reference) and after adding plasma NfL (+NFL) or p-tau181 levels (+PTAU) in both the CN and CI groups. *, p-value < 0.05

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