Baseline cognition is the best predictor of 4-year cognitive change in cognitively intact older adults

Table 3 Whole-brain linear regression analysis of episodic memory decline neural correlates

Region	MNI coordinates			Extent	P _FWE	Z
	x	y	z
Right medial temporal cortex	20	2	−39	1686	0.002	4.03
	21	−19	−23			3.98
	32	−15	−15			3.97
Dorsomedial thalamus	6	−9	1	1402	0.006	4.46
	3	−18	−2			4.31
Left cerebellar crus II	−30	−72	−42	1360	0.007	3.99
	−41	−60	−45			3.74

Peak coordinates of the whole-brain voxelwise linear regression analyses across 179 subjects with the individual modulated grey matter maps as dependent variable, and Buschke Selective Reminding Test total retention slopes as index for episodic memory decline as independent variable. ICV is used as covariate of no interest. The significance threshold was set at voxel-level uncorrected P value <0.001, with a cluster-level whole-brain FWE-corrected threshold P value <0.05. MNI coordinates (x, y and z) are in mm. Extent corresponds to the number of grey matter voxels within a cluster, of which the voxel size was 1.5 mm³

ISSN: 1758-9193