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Fig. 4 | Alzheimer's Research & Therapy

Fig. 4

From: Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport

Fig. 4

The levels of KIF5 family members did not differ from controls in the brains of young and aged Dp16 mice. Western blotting analysis of the levels of KIF5 family members in the brains from young (4 m, a) and aged (16 m, c) Dp16 mice. fl-mAPP was also probed; β-actin was used as a loading control. The left panels show representative immunoblots, while the right panels display the quantitation and statistical analysis. b Spearman’s correlation analysis of KIF5 members in the 2N and Dp16 samples taken together (4 months old). Mann-Whitney test. n = 4–9 mice for each category in a and c and n = 14 in b (7 2N and 7 Dp16); ***P < 0.001 unless stated. n.s., non-significant

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