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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport

Fig. 2

Neither the levels of KIF5 family members nor APP were changed in the frontal cortex of AD brain. a Western blotting of KIF5 levels in protein extracts from the frontal cortex of patients with AD and C/AD. fl-hAPP was also probed. β-Actin and GAPDH were each used as loading controls. b Quantitation and statistical analysis of the levels of fl-hAPP in AD and C/AD. c Quantitation and statistical analysis of the levels of KIF5 family members in AD and C/AD. d Spearman’s correlation analysis of KIF5 members in combined C/AD and AD samples; the red dotted lines mark the 95% confidence interval. Insert with the same diagram indicates the distribution of C/AD and AD samples. e Quantitation and statistical analysis of the levels of KIF5 family members in females and males from AD and C/AD samples. f Spearman’s correlation analyses for age and the levels of KIF5 members in AD and C/AD. n = 12 for both C/AD and AD patients; Mann-Whitney test in b, c, and e. n.s., non-significant; F, female; M, male

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