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Fig. 5 | Alzheimer's Research & Therapy

Fig. 5

From: Genome-wide epistasis analysis for Alzheimer’s disease and implications for genetic risk prediction

Fig. 5

Associations between CRSs_1e-5 (combined risk scores constructed by genetic interactions with P < 1 × 10−5) and Alzheimer’s disease pathologies. a CRSs were negatively correlated with CSF Aβ1–42 (AD (n = 388): R = −0.41, P = 8.4 × 10−17; non-AD (n = 655): R = − 0.35, P = 7.1 × 10−20). b CRSs showed a positive correlation with CSF total tau (AD (n = 388): R = 0.088, P = 0.082; non-AD (n = 655): R = 0.19, P = 5.8 × 10−7). c CRSs showed a positive correlation with phosphorylated tau (AD (n = 388): R = 0.12, P = 0.018; non-AD (n = 655): R = 0.23, P = 2.3 × 10−9)

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