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Fig. 4 | Alzheimer's Research & Therapy

Fig. 4

From: Genome-wide epistasis analysis for Alzheimer’s disease and implications for genetic risk prediction

Fig. 4

Performance of epistasis risk scores (ERSs), polygenic risk scores (PRSs), and combined risk scores (CRSs) in AD risk prediction using samples from ADNI. Samples were divided into four quantiles (Q1 to Q4: from the lowest risk to the highest risk) based on their ERSs. The probability of developing AD was analyzed by the Kaplan-Meier method, where the P value was obtained by the log-rank test. ERSs were obtained via interactions with a P < 1 × 10−7 (298 interactions), b P < 1 × 10−6 (2478 interaction), or c P < 1 × 10−5 (19,264 interactions). d Comparison of AUCs of ERSs, PRSs, and CRSs in identifying AD patients. ERS_1e-5: ERSs constructed by genetic interactions with P value smaller than 1 × 10−5; PRS_GWAS: PRSs constructed by APOE (rs7412 and rs429358) and 20 SNPs identified by previous GWAS; CRS_1e-7, CRS_1e-6, CRS_1e-5: combined risk score of SNPs and SNP-SNP interactions with P value smaller than 1 × 10−7, 1 × 10−6, or 1 × 10−5; CRS_selected: similar to CRS_1e-5, except that only 77 genetic interactions showing non-random effects in ROS/MAP and ADNI were included

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