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Fig. 10 | Alzheimer's Research & Therapy

Fig. 10

From: Development of a novel, sensitive translational immunoassay to detect plasma glial fibrillary acidic protein (GFAP) after murine traumatic brain injury

Fig. 10

Plasma GFAP levels are elevated in aged APP/PS1 mice and APP/PS1 mice lacking apoA-I. a Female APP/PS1 mice (on a mixed C3H/Bl6 background) were aged to 3, 6, 9, 12, 18, or 24 months old then plasma specimens were collected by cardiac puncture. Mean plasma GFAP concentrations of each group are plotted with points representing individual mouse plasma samples and error bars representing ±SD. The effects of age and APP/PS1 genotype on plasma GFAP concentration were analyzed by two-way ANOVA (exact p values below graph) followed by Tukey’s multiple comparisons test across genotypes (exact p values below graph) or Sidak’s multiple comparison’s test within each genotype (detailed within graph, **p < 0.01, ***p < 0.001). b Male and female apoA-I hemizygous (apoA-IHEM) or knockout (apoA-IKO) mice with or without APP/PS1 transgenes (on a C57Bl/6 background) were aged to 12 months old then plasma specimens were collected by cardiac puncture. Mean plasma GFAP concentrations of each group are plotted with points representing individual mouse plasma samples and error bars representing ±SD. The effects APP/PS1 genotype and apoA-I genotype on plasma GFAP concentration were analyzed by two-way ANOVA (exact p values below graph) followed by Sidak’s multiple comparisons test (detailed within graph *p < 0.05, **p < 0.01). apoA-I: apolipoprotein A-I, SD: standard deviation

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