Skip to main content

Table 3 Linear regression models of cognition, core and suggestive features, and disease burden

From: Characterization of symptoms and determinants of disease burden in dementia with Lewy bodies: DEvELOP design and baseline results

Symptom

FAQ

QoL-AD

ZBI

Model 1

Model 2

Model 1

Model 2

Model 1

Model 2

Visual hallucinations

2.48 ± 1.21*

 

−1.47 ± 1.08

 

−2.30 ± 3.50

 

Parkinsonism

3.42 ± 1.34*

2.29 ± 1.23+

−1.79 ± 1.19

 

6.28 ± 3.85

 

RBD

2.07 ± 1.39

 

0.67 ± 1.24

 

4.33 ± 4.09

 

Cognitive fluctuations

4.75 ± 1.15*

4.40 ± 1.12*

−1.46 ± 1.10

 

5.73 ± 3.61

 

Orthostatic hypotension

0.49 ± 1.26

 

−1.16 ± 1.11

 

0.39 ± 3.59

 

Constipation

0.74 ± 1.36

 

−3.09 ± 1.15*

−2.16 ± 1.07*

5.37 ± 3.96

 

Urinary problems

−0.92 ± 1.19

 

0.55 ± 1.04

 

−4.61 ± 3.34

 

Depression

1.12 ± 1.58

 

−4.64 ± 1.31*

−4.25 ± 1.29*

7.02 ± 4.31

 

Apathy

2.87 ± 1.20*

2.11 ± 1.10+

−1.06 ± 1.09

 

13.59 ± 3.11*

11.01 ± 2.79*

Anxiety

1.19 ± 1.22

 

−0.73 ± 1.08

 

5.42 ± 3.32

 

MMSE

−0.94 ± 0.21*

− 0.60 ± 0.20*

0.15 ± 0.19

 

−1.12 ± 0.60+

 

IADL (FAQ)

–

–

−0.20 ± 0.09*

−0.17 ± 0.08*

1.29 ± 0.25*

−1.07 ± 0.21*

  1. Data represent β ± SE. Model 1: with correction for age, sex, and MMSE. Model 2: after backwards selection with significant determinants of model 1, corrected for age, sex, and MMSE
  2. Abbreviations: FAQ Functional Activities Questionnaire (higher scores indicate lower IADL functioning), QoL-AD Quality of Life-Alzheimer’s Disease (higher scores indicate higher quality of life), ZBI Zarit Caregiver Burden Interview (higher scores indicate higher caregiver burden), RBD rapid eye movement sleep behavior disorder, QPE Questionnaire on Psychotic Events, NPI Neuropsychiatric Inventory, UPDRS Unified Parkinson’s Disease Rating Scale, MMSE Mini-Mental State Examination
  3. *p < 0.05
  4. +p < 0.1