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Table 2 Baseline characteristics

From: Characterization of symptoms and determinants of disease burden in dementia with Lewy bodies: DEvELOP design and baseline results

Domain

Measurement

Total (n = 100)

Dementia (n = 73)

MCI (n = 27)

n available

Demographics

Sex, n female (%)

10 (10%)

8 (11%)

2 (7%)

100

Age, years

69 ± 6

70 ± 5

67 ± 7

100

Disease duration, years

4 ± 3

4 ± 3

4 ± 2

99

Education, years

12 ± 3

12 ± 3

12 ± 3

100

MMSE

25 ± 3

24 ± 3

27 ± 2

100

APOE-e4 carrier

39 (47%)

26 (47%)

10 (46%)

77

Core clinical features

Parkinsonism

69 (69%)

54 (75%)

15 (56%)

99

Visual hallucinations

39 (39%)

32 (44%)

7 (27%)

99

Cognitive fluctuations

45 (46%)

38 (53%)

7 (27%)*

98

RBD

75 (77%)

55 (76%)

20 (77%)

98

Suggestive neuropsychiatric symptoms

Depressive symptoms

18 (19%)

14 (20%)

4 (16%)

95

Delusions

7 (7%)

7 (10%)

0

99

Anxiety

40 (44%)

31 (44%)

9 (41%)

92

Apathy

56 (61%)

45 (64%)

11 (50%)

92

Suggestive autonomic symptoms

Orthostatic hypotension

63 (64%)

46 (63%)

17 (65%)

99

Constipation

34 (34%)

29 (40%)

5 (19%)*

100

Urinary problems

47 (47%)

33 (45%)

14 (52%)

100

Hynosmia

52 (54%)

40 (56%)

12 (46%)

97

Assessment of disease burden

Functional Activities Questionnaire

12 ± 6

13 ± 6

8 ± 6*

98

Quality of Life-AD

31 ± 5

31 ± 5

31 ± 5

100

Zarit caregiver burden interview

25 ± 15

26 ± 14

19 ± 16

77

Imaging

123FP-CIT-SPECT, n abnormal (%)

70 (88%)

47 (87%)

22 (88%)

80

Medial temporal atrophy

1 [0.5–1.5]

1 [0.5–1.5]

0.5 [0–1]*

95

Posterior cortical atrophy

1 [1–2]

1 [1–2]

1 [0.5–1]

95

Global cortical atrophy

1 [0–1]

1 [0–1]

0 [0–1]*

95

Fazekas

1 [0–1]

1 [1–1]

0 [0–1]

94

Microbleeds, presence, n (%)

12 (13%)

8 (12%)

4 (17%)

90

EEG/MEG (n = 68/n = 7)

Abnormal EEG/MEG (severity ≥2)

72 (96%)

52 (98%)

20 (91%)

75

Severe abnormal EEG/MEG (severity = 3)

60 (80%)

46 (89%)

14 (64%)*

75

CSF

Aβ42, n abnormal (%)

51 (70%)

39 (74%)

12 (60%)

73

t-tau, n abnormal (%)

27 (37%)

19 (36%)

8 (40%)

73

p-tau, n abnormal (%)

29 (40%)

20 (38%)

9 (45%)

73

p-tau/Aβ42, n abnormal (%)

39 (53%)

30 (57%)

9 (45%)

73

  1. Data represent n (%), mean ± SD, or median [IQR]
  2. Abbreviations: MMSE Mini-Mental State Examination, MCI mild cognitive impairment, RBD rapid eye movement sleep behavior disorder, GDS Geriatric Depression Scale, QPE Questionnaire on Psychotic Experiences, NPI Neuropsychiatric Inventory, NMSS Non-Motor Symptoms Scale
  3. *p < 0.05 compared to dementia