Fig. 3
From: Human neural stem cell-derived extracellular vesicles mitigate hallmarks of Alzheimer’s disease
a–c Early-stage AD behavioral testing indicated no impairments on novel object recognition (NOR) or light-dark box (LDB) tests, but AD mice showed increased anxiety-like behavior on the elevated plus maze (EPM) test that was mitigated by EV treatment. d–f Late-stage AD mice exhibited no significant impairments on NOR or EPM tests, but increased anxiety-like behavior on the LDB test that was mitigated by EV treatment as shown by an increased number of transitions between the light-dark compartments. Data are presented as mean ± SEM where N = 14–16 mice/group. P values are derived from ANOVA and Bonferroni’s multiple comparisons test. *P < 0.05, **P < 0.01 as compared to AD