Table 4 Cross-sectional associations between 27-OH, cognition, and neuroimaging markers at baseline
Model 1, β (p) | Model 2, β (p) | Model 3, β (p) | |
|---|---|---|---|
Cognition | |||
NTB total composite | −0.28 (0.04) | −0.42 (0.01) | −0.22 (0.12) |
NTB memory | −0.36 (0.01) | −0.59 (0.00) | −0.27 (0.08) |
NTB processing speed | −0.20 (0.20) | −0.27 (0.14) | −0.16 (0.34) |
NTB executive function | −0.09 (0.53) | −0.08 (0.62) | −0.08 (0.57) |
MRI | |||
Total gray matter volume | −0.27 (0.09) | −0.45 (0.01) | −0.08 (0.61) |
Hippocampal volume | −0.31 (0.04) | −0.48 (0.00) | −0.14 (0.31) |
AD signature cortical thickness | 0.01 (0.98) | 0.01 (0.96) | −0.15 (0.42) |
White matter lesion volume | 0.24 (0.13) | 0.31 (0.10) | 0.21 (0.22) |
FDG-PET | |||
Cortical composite | −0.22 (0.16) | −0.27 (0.11) | −0.08 (0.66) |
Prefrontal cortex | −0.03 (0.86) | −0.04 (0.82) | −0.08 (0.66) |
Parietal cortex | −0.27 (0.09) | −0.30 (0.09) | −0.16 (0.38) |
Lateral temporal cortex | −0.21 (0.21) | −0.27 (0.14) | −0.13 (0.48) |
Precuneus | −0.28 (0.10) | −0.32 (0.09) | −0.11 (0.55) |
Anterior cingulate gyrus | −0.17 (0.27) | −0.20 (0.24) | −0.09 (0.62) |
Posterior cingulate gyrus | −0.20 (0.23) | −0.30 (0.08) | −0.02 (0.91) |
Medial temporal cortex | −0.02 (0.90) | −0.14 (0.44) | −0.05 (0.80) |
Lateral occipital cortex | −0.31 (0.07) | −0.29 (0.11) | −0.40 (0.04) |
Striatum | −0.28 (0.10) | −0.26 (0.15) | −0.27 (0.16) |
Cerebellum | 0.00 (0.98) | −0.05 (0.81) | 0.21 (0.25) |
PIB-PET | |||
Cortical composite | −0.06 (0.73) | −0.08 (0.67) | −0.02 (0.91) |