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Table 1 Baseline characteristics of the control and intervention groups

From: 27-Hydroxycholesterol, cognition, and brain imaging markers in the FINGER randomized controlled trial

 

Number

Control, mean (SD)

Number

Intervention, mean (SD)

p

Demographic characteristics

 Sex, % men/women

11/12

47.8/52.2

15/9

62.5/37.5

0.30

 Age, years

23

70.1 (4.7)

24

71.2 (5.4)

0.46

 Years of education

23

9.3 (2.5)

24

9.1 (2.4)

0.76

 Smokers, %, no/yes

20/2

90.9/9.1

23/1

95.8/4.2

0.51

 ApoE4 carrier, %, no/yes

16/6

72.7/27.3

16/8

66.7/33.3

0.70

 ApoE allele frequencies

e2/e3

1

 

1

  

e2/e4

0

 

2

  

e3/e3

15

 

15

  

e3/e4

5

 

6

  

e4/e4

1

 

0

  

Serum measurements

 27-OH, ng/ml

23

176.48 (48.39)

24

182.42 (49.28)

0.68

 Total cholesterol, mmol/l

23

4.87 (1.06)

24

4.99 (1.00)

0.69

Cognition

 NTB total composite

23

0.01 (0.54)

24

−0.04 (0.53)

0.75

 NTB memory

23

0.02 (0.64)

24

−0.14 (0.52)

0.35

 NTB processing speed

23

0.14 (0.74)

24

−0.03 (1.05)

0.53

 NTB executive function

23

−0.09 (0.56)

24

0.07 (0.58)

0.35

MRI

 *Total gray matter volume, ml

23

568.35 (59.35)

24

582.86 (51.80)

0.38

 *Total hippocampal volume, ml

23

7.20 (0.94)

24

7.73 (0.99)

0.07

 AD signature cortical thickness, mm

20

2.73 (0.13)

19

2.72 (0.10)

0.70

 *White matter lesion volume, ml

23

12.49 (16.49)

23

14.06 (16.18)

0.75

 Total intracranial volume, ml

23

1540.64 (257.41)

24

1556.66 (252.14)

0.83

FDG-PET

 Cortical composite

23

1.23 (0.07)

22

1.19 (0.08)

0.03

 Prefrontal cortex

23

1.35 (0.08)

22

1.27 (0.09)

0.01

 Parietal cortex

23

1.24 (0.10)

22

1 19 (0.08)

0.05

 Lateral temporal cortex

23

1.02 (0.05)

22

0.99 (0.05)

0.10

 Precuneus

23

1.38 (0.12)

22

1.33 (0.10)

0.13

 Anterior cingulate gyrus

23

1.12 (0.08)

22

1.08 (0.10)

0.14

 Posterior cingulate gyrus

23

1.29 (0.09)

22

1.24 (0.11)

0.09

 Medial temporal cortex

23

0.79 (0.05)

22

0.78 (0.06)

0.48

 Lateral occipital cortex

23

1.17 (0.08)

22

1.15 (0.09)

0.37

 Striatum

23

1.19 (0.10)

22

1.13 (0.10)

0.07

 Cerebellum

23

1.02 (0.01)

22

1.02 (0.01)

0.66

PiB PET

 Cortical composite

23

1.57 (0.37)

24

1.46 (0.38)

0.34

  1. Values are means ± SD unless otherwise specified. Between-group differences were analyzed with the chi-square and t tests as appropriate. p value considered significant (marked in bold) if < 0.05. Cognitive scores are mean values of Z-scores of the cognitive tests included in each cognitive outcome, where higher scores indicate better performance. *Brain volumes are shown unadjusted; corresponding p values are shown from analyses with values adjusted for total intracranial volume and zero-skewness log-transformed as appropriate. AD signature cortical thickness was calculated as the average of cortical thickness in the entorhinal, inferior temporal, middle temporal, and fusiform regions. The composite scores for FDG-PET and PiB-PET were determined as the average of the prefrontal, parietal, lateral temporal, anterior cingulate, posterior cingulate, and precuneus ROIs
  2. ApoE4, apolipoprotein E4; NTB, neuropsychological test battery; MRI, magnetic resonance imaging; AD, Alzheimer’s disease; FDG-PET, 2-deoxy-2fluorine-18fluoro-d-glucose positron emission tomography; PiB, 11 C-Pittsburgh compound B
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Alzheimer's Research & Therapy

ISSN: 1758-9193