Table 2 Proteins displaying significant slope differences between A+ and A− individuals sorted by t-tau rho

β-synuclein

SNCB

Q16143

HPA035876

0.20

4E−02

0.80

6E−69

2E−05

0.79

8E−65

ns

Rabphilin-3A

RPH3A

Q9Y2J0

HPA002475

0.26

4E−04

0.80

1E−67

4E−07

0.79

4E−65

4E−03

Brain acid-soluble protein 1

BASP1

P80723

HPA050333

0.21

2E−02

0.79

8E−66

2E−08

0.78

1E−61

5E−04

Neuromodulin

GAP43

P17677

PA5–34943

ns

ns

0.79

5E−65

2E−06

0.78

1E−61

9E−03

Neural cell adhesion molecule L1-like protein

CHL1

O00533

HPA003345

0.30

7E−06

0.77

2E−60

1E−09

0.77

1E−58

1E−05

Cadherin-8

CDH8

P55286

HPA014908

0.28

5E−05

0.75

1E−55

3E−09

0.75

7E−54

2E−05

Lymphocyte antigen 6H

LY6H

O94772

HPA077218

0.25

8E−04

0.75

2E−54

4E−10

0.75

4E−54

2E−06

Transmembrane protein 132D

TMEM132D

Q14C87

HPA010739

0.28

1E−04

0.75

5E−54

8E−12

0.75

6E−54

3E−08

Cell cycle exit and neuronal differentiation protein 1

CEND1

Q8N111

HPA042527

ns

ns

0.74

2E−53

4E−06

0.72

2E−48

8E−03

SLIT and NTRK like family member 1

SLITRK1

Q96PX8

HPA012414

0.21

2E−02

0.74

7E−53

2E−08

0.73

3E−50

2E−04

Cell adhesion molecule 2

CADM2

Q8N3J6

HPA010024

0.31

5E−06

0.74

6E−52

1E−04

0.73

1E−50

4E−02

Oligodendrocyte-myelin glycoprotein

OMG

P23515

HPA008206

0.31

4E−06

0.71

2E−46

5E−06

0.72

2E−48

9E−04

Voltage-dependent calcium channel subunit alpha-2/delta-1

CACNA2D1

P54289

HPA008213

0.31

3E−06

0.71

5E−46

9E−07

0.71

3E−47

5E−04

Neurosecretory protein VGF

VGF

O15240

HPA055177

0.29

3E−05

0.71

2E−45

1E−03

0.71

3E−47

ns

Neuronal cell adhesion molecule

NRCAM

Q92823

HPA061433

0.33

7E−07

0.70

1E−44

3E−08

0.72

2E−47

6E−06

Neurocan core protein

NCAN

O14594

HPA058000

0.28

1E−04

0.69

5E−43

6E−06

0.70

1E−44

3E−03

Amyloid-like protein 1

APLP1

P51693

HPA028971

0.31

6E−06

0.69

1E−42

6E−07

0.69

2E−43

1E−04

Extracellular matrix protein 1

ECM1

Q16610

HPA027241

0.27

3E−04

0.69

4E−42

4E−08

0.68

2E−41

2E−05

Amphiphysin

AMPH

P49418

HPA019828

ns

ns

0.69

6E−42

3E−03

0.68

2E−41

ns

Cholecystokinin

CCK

P06307

HPA069515

0.30

1E−05

0.67

7E−40

5E−06

0.66

9E−38

5E−04

Calsyntenin-1

CLSTN1

O94985

HPA012749

0.31

5E−06

0.67

3E−39

2E−04

0.67

2E−39

2E−02

Neurofascin

NFASC

O94856

HPA073444

0.24

2E−03

0.66

4E−38

4E−06

0.66

3E−38

2E−04

Phosphoinositide-3-kinase-interacting protein 1

PIK3IP1

Q96FE7

HPA002959

0.28

8E−05

0.66

4E−37

9E−07

0.65

1E−35

5E−04

Peptidyl-glycine alpha-amidating monooxygenase

PAM

P19021

HPA042260

0.30

1E−05

0.66

4E−37

2E−04

0.65

8E−36

4E−02

Phosphatidyl-ethanolamine-binding protein 1

PEBP1

P30086

HPA063904

ns

ns

0.65

9E−37

3E−03

0.67

8E−39

ns

Dickkopf-related protein 3

DKK3

Q9UBP4

HPA011164

0.21

2E−02

0.65

2E−36

1E−02

0.66

3E−37

ns

Neuronal pentraxin receptor

NPTXR

O95502

HPA001079

0.27

3E−04

0.64

2E−35

3E−03

0.67

5E−39

4E−02

Vasorin

VASN

Q6EMK4

HPA011246

0.21

2E−02

0.64

2E−34

5E−04

0.64

1E−34

ns

Neuronal pentraxin-1

NPTX1

Q15818

HPA077062

0.32

1E−06

0.61

2E−30

2E−02

0.61

8E−31

ns

Multiple epidermal growth factor-like domains protein 10

MEGF10

Q96KG7

HPA026876

0.24

3E-03

0.60

1E−29

6E−03

0.61

9E−31

ns

Myelin oligodendrocyte glycoprotein

MOG

Q16653

AMAb91067

0.23

6E−03

0.54

1E−22

2E−04

0.54

4E−22

1E−02

Synaptotagmin-11

SYT11

Q9BT88

HPA064091

ns

ns

0.54

2E−22

2E−02

0.54

4E−22

ns

Pro-opiomelanocortin

POMC

P01189

HPA063644

0.22

2E−02

0.49

4E−18

2E−04

0.49

7E−18

7E−03