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Table 2 Proteins displaying significant slope differences between A+ and A− individuals sorted by t-tau rho

From: Association of CSF proteins with tau and amyloid β levels in asymptomatic 70-year-olds

     Aβ42 concentration T-tau concentration P-tau concentration
Protein name HGNC ID Uniprot ID Antibody rho p rho p p (slope) rho p p (slope)
β-synuclein SNCB Q16143 HPA035876 0.20 4E−02 0.80 6E−69 2E−05 0.79 8E−65 ns
Rabphilin-3A RPH3A Q9Y2J0 HPA002475 0.26 4E−04 0.80 1E−67 4E−07 0.79 4E−65 4E−03
Brain acid-soluble protein 1 BASP1 P80723 HPA050333 0.21 2E−02 0.79 8E−66 2E−08 0.78 1E−61 5E−04
Neuromodulin GAP43 P17677 PA5–34943 ns ns 0.79 5E−65 2E−06 0.78 1E−61 9E−03
Neural cell adhesion molecule L1-like protein CHL1 O00533 HPA003345 0.30 7E−06 0.77 2E−60 1E−09 0.77 1E−58 1E−05
Cadherin-8 CDH8 P55286 HPA014908 0.28 5E−05 0.75 1E−55 3E−09 0.75 7E−54 2E−05
Lymphocyte antigen 6H LY6H O94772 HPA077218 0.25 8E−04 0.75 2E−54 4E−10 0.75 4E−54 2E−06
Transmembrane protein 132D TMEM132D Q14C87 HPA010739 0.28 1E−04 0.75 5E−54 8E−12 0.75 6E−54 3E−08
Cell cycle exit and neuronal differentiation protein 1 CEND1 Q8N111 HPA042527 ns ns 0.74 2E−53 4E−06 0.72 2E−48 8E−03
SLIT and NTRK like family member 1 SLITRK1 Q96PX8 HPA012414 0.21 2E−02 0.74 7E−53 2E−08 0.73 3E−50 2E−04
Cell adhesion molecule 2 CADM2 Q8N3J6 HPA010024 0.31 5E−06 0.74 6E−52 1E−04 0.73 1E−50 4E−02
Oligodendrocyte-myelin glycoprotein OMG P23515 HPA008206 0.31 4E−06 0.71 2E−46 5E−06 0.72 2E−48 9E−04
Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 P54289 HPA008213 0.31 3E−06 0.71 5E−46 9E−07 0.71 3E−47 5E−04
Neurosecretory protein VGF VGF O15240 HPA055177 0.29 3E−05 0.71 2E−45 1E−03 0.71 3E−47 ns
Neuronal cell adhesion molecule NRCAM Q92823 HPA061433 0.33 7E−07 0.70 1E−44 3E−08 0.72 2E−47 6E−06
Neurocan core protein NCAN O14594 HPA058000 0.28 1E−04 0.69 5E−43 6E−06 0.70 1E−44 3E−03
Amyloid-like protein 1 APLP1 P51693 HPA028971 0.31 6E−06 0.69 1E−42 6E−07 0.69 2E−43 1E−04
Extracellular matrix protein 1 ECM1 Q16610 HPA027241 0.27 3E−04 0.69 4E−42 4E−08 0.68 2E−41 2E−05
Amphiphysin AMPH P49418 HPA019828 ns ns 0.69 6E−42 3E−03 0.68 2E−41 ns
Cholecystokinin CCK P06307 HPA069515 0.30 1E−05 0.67 7E−40 5E−06 0.66 9E−38 5E−04
Calsyntenin-1 CLSTN1 O94985 HPA012749 0.31 5E−06 0.67 3E−39 2E−04 0.67 2E−39 2E−02
Neurofascin NFASC O94856 HPA073444 0.24 2E−03 0.66 4E−38 4E−06 0.66 3E−38 2E−04
Phosphoinositide-3-kinase-interacting protein 1 PIK3IP1 Q96FE7 HPA002959 0.28 8E−05 0.66 4E−37 9E−07 0.65 1E−35 5E−04
Peptidyl-glycine alpha-amidating monooxygenase PAM P19021 HPA042260 0.30 1E−05 0.66 4E−37 2E−04 0.65 8E−36 4E−02
Phosphatidyl-ethanolamine-binding protein 1 PEBP1 P30086 HPA063904 ns ns 0.65 9E−37 3E−03 0.67 8E−39 ns
Dickkopf-related protein 3 DKK3 Q9UBP4 HPA011164 0.21 2E−02 0.65 2E−36 1E−02 0.66 3E−37 ns
Neuronal pentraxin receptor NPTXR O95502 HPA001079 0.27 3E−04 0.64 2E−35 3E−03 0.67 5E−39 4E−02
Vasorin VASN Q6EMK4 HPA011246 0.21 2E−02 0.64 2E−34 5E−04 0.64 1E−34 ns
Neuronal pentraxin-1 NPTX1 Q15818 HPA077062 0.32 1E−06 0.61 2E−30 2E−02 0.61 8E−31 ns
Multiple epidermal growth factor-like domains protein 10 MEGF10 Q96KG7 HPA026876 0.24 3E-03 0.60 1E−29 6E−03 0.61 9E−31 ns
Myelin oligodendrocyte glycoprotein MOG Q16653 AMAb91067 0.23 6E−03 0.54 1E−22 2E−04 0.54 4E−22 1E−02
Synaptotagmin-11 SYT11 Q9BT88 HPA064091 ns ns 0.54 2E−22 2E−02 0.54 4E−22 ns
Pro-opiomelanocortin POMC P01189 HPA063644 0.22 2E−02 0.49 4E−18 2E−04 0.49 7E−18 7E−03