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Table 3 The rate of cognitive decline in Focal-FMM compared to No- or Diffuse-FMM uptake in each location of FMM uptake

From: Cognitive trajectories of patients with focal ß-amyloid deposition

  Frontal (n = 29) PPC (n = 28) Temporal (n = 14) Parietal (n = 26) Striatum (n = 21)
Beta (SE) p beta (SE) p Beta (SE) p Beta (SE) p Beta (SE) p
Global cognition (CDR-SB*)
 Ref: No-FMM 0.74 (0.25) 0.003† 0.85 (0.25) 0.001† 0.44 (0.36) 0.224 0.64 (0.25) 0.012 0.94 (0.29) 0.001†
 Ref: Diffuse-FMM − 0.63 (0.27) 0.020 − 0.51 (0.27) 0.060 − 0.92 (0.37) 0.014 − 0.73 (0.27) 0.008† − 0.43 (0.31) 0.166
Cognitive subdomains
Frontal-executive (Stroop test)
  Ref: No-FMM − 0.11 (0.12) 0.352 − 0.18 (0.12) 0.142 − 0.17 (0.18) 0.351 − 0.08 (0.12) 0.495 − 0.11 (0.14) 0.423
  Ref: Diffuse-FMM 0.14 (0.13) 0.277 0.07 (0.13) 0.582 0.09 (0.19) 0.641 0.17 (0.13) 0.201 0.14 (0.15) 0.337
Language (K-BNT)
  Ref: No-FMM − 0.13 (0.10) 0.185 − 0.23 (0.10) 0.021 − 0.20 (0.14) 0.165 − 0.15 (0.10) 0.136 − 0.15 (0.11) 0.19
  Ref: Diffuse-FMM 0.14 (0.11) 0.192 0.04 (0.11) 0.735 0.07 (0.15) 0.658 0.12 (0.11) 0.278 0.12 (0.12) 0.319
Memory (verbal memory)
  Ref: No-FMM − 0.23 (0.10) 0.022 − 0.33 (0.10) 0.001†† − 0.21 (0.15) 0.165 − 0.08 (0.10) 0.425 − 0.23 (0.12) 0.048
  Ref: Diffuse-FMM 0.03 (0.11) 0.767 − 0.07 (0.11) 0.492 0.05 (0.15) 0.745 0.18 (0.11) 0.113 0.03 (0.12) 0.824
Visuospatial (figure copying)
  Ref: No-FMM − 0.37 (0.18) 0.045 − 0.52 (0.19) 0.007 − 0.06 (0.28) 0.836 − 0.56 (0.19) 0.004 − 0.49 (0.21) 0.022
  Ref: Diffuse-FMM − 0.23 (0.20) 0.246 − 0.38 (0.21) 0.066 0.08 (0.29) 0.789 − 0.42 (0.21) 0.044 − 0.35 (0.23) 0.119
  1. FMM 18F-flutemetamol, PPC precuneus/posterior cingulate, SE standard error, K-BNT Korean version-Boston Naming Test, CDR-SB Clinical Dementia Rating Scale Sum of Boxes
  2. *Values were adjusted for age and education
  3. p < 0.05 after Bonferroni correction for 5 tests (5 regions)
  4. ††p < 0.05 after Bonferroni correction for 20 tests (5 regions and 4 cognitive subdomains)
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