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Table 3 The rate of cognitive decline in Focal-FMM compared to No- or Diffuse-FMM uptake in each location of FMM uptake

From: Cognitive trajectories of patients with focal ß-amyloid deposition

 

Frontal (n = 29)

PPC (n = 28)

Temporal (n = 14)

Parietal (n = 26)

Striatum (n = 21)

Beta (SE)

p

beta (SE)

p

Beta (SE)

p

Beta (SE)

p

Beta (SE)

p

Global cognition (CDR-SB*)

 Ref: No-FMM

0.74 (0.25)

0.003†

0.85 (0.25)

0.001†

0.44 (0.36)

0.224

0.64 (0.25)

0.012

0.94 (0.29)

0.001†

 Ref: Diffuse-FMM

− 0.63 (0.27)

0.020

− 0.51 (0.27)

0.060

− 0.92 (0.37)

0.014

− 0.73 (0.27)

0.008†

− 0.43 (0.31)

0.166

Cognitive subdomains

Frontal-executive (Stroop test)

  Ref: No-FMM

− 0.11 (0.12)

0.352

− 0.18 (0.12)

0.142

− 0.17 (0.18)

0.351

− 0.08 (0.12)

0.495

− 0.11 (0.14)

0.423

  Ref: Diffuse-FMM

0.14 (0.13)

0.277

0.07 (0.13)

0.582

0.09 (0.19)

0.641

0.17 (0.13)

0.201

0.14 (0.15)

0.337

Language (K-BNT)

  Ref: No-FMM

− 0.13 (0.10)

0.185

− 0.23 (0.10)

0.021

− 0.20 (0.14)

0.165

− 0.15 (0.10)

0.136

− 0.15 (0.11)

0.19

  Ref: Diffuse-FMM

0.14 (0.11)

0.192

0.04 (0.11)

0.735

0.07 (0.15)

0.658

0.12 (0.11)

0.278

0.12 (0.12)

0.319

Memory (verbal memory)

  Ref: No-FMM

− 0.23 (0.10)

0.022

− 0.33 (0.10)

0.001††

− 0.21 (0.15)

0.165

− 0.08 (0.10)

0.425

− 0.23 (0.12)

0.048

  Ref: Diffuse-FMM

0.03 (0.11)

0.767

− 0.07 (0.11)

0.492

0.05 (0.15)

0.745

0.18 (0.11)

0.113

0.03 (0.12)

0.824

Visuospatial (figure copying)

  Ref: No-FMM

− 0.37 (0.18)

0.045

− 0.52 (0.19)

0.007

− 0.06 (0.28)

0.836

− 0.56 (0.19)

0.004

− 0.49 (0.21)

0.022

  Ref: Diffuse-FMM

− 0.23 (0.20)

0.246

− 0.38 (0.21)

0.066

0.08 (0.29)

0.789

− 0.42 (0.21)

0.044

− 0.35 (0.23)

0.119

  1. FMM 18F-flutemetamol, PPC precuneus/posterior cingulate, SE standard error, K-BNT Korean version-Boston Naming Test, CDR-SB Clinical Dementia Rating Scale Sum of Boxes
  2. *Values were adjusted for age and education
  3. p < 0.05 after Bonferroni correction for 5 tests (5 regions)
  4. ††p < 0.05 after Bonferroni correction for 20 tests (5 regions and 4 cognitive subdomains)