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Table 2 The rate of cognitive decline in the Focal-FMM uptake compared to the No- or Diffuse- FMM uptake in each cognitive level

From: Cognitive trajectories of patients with focal ß-amyloid deposition

  Total (n = 240) CU (n = 112) aMCI (n = 78) ADD (n = 50)
Beta (SE) p Beta (SE) p Beta (SE) p Beta (SE) p
Global cognition (CDR-SB*)
 Ref: No-FMM 0.53 (0.20) 0.009 0.22 (0.10) 0.031 0.83 (0.38) 0.028 0.36 (0.98) 0.716
 Ref: Diffuse-FMM − 0.84 (0.22) < 0.001 − 0.32 (0.16) 0.040 − 0.26 (0.38) 0.505 − 0.86 (0.66) 0.200
Cognitive subdomains
Frontal-executive (Stroop test)
  Ref: No-FMM − 0.09 (0.09) 0.361 0.01 (0.10) 0.944 − 0.39 (0.19) 0.042 0.22 (0.36) 0.543
  Ref: Diffuse-FMM 0.17 (0.11) 0.115 0.16 (0.15) 0.281 − 0.22 (0.19) 0.268 0.41 (0.26) 0.12
Language (K-BNT)
  Ref: No-FMM − 0.12 (0.08) 0.133 − 0.08 (0.09) 0.385 − 0.23 (0.17) 0.177 − 0.01 (0.24) 0.976
  Ref: Diffuse-FMM 0.15 (0.09) 0.088 − 0.15 (0.14) 0.263 0.02 (0.17) 0.915 0.24 (0.17) 0.169
Memory (verbal memory)
  Ref: No-FMM − 0.15 (0.08) 0.064 − 0.07 (0.11) 0.544 − 0.32 (0.18) 0.078 − 0.14 (0.13) 0.288
  Ref: Diffuse-FMM 0.11 (0.09) 0.244 0.53 (0.17) 0.003† − 0.001 (0.19) 0.996 − 0.14 (0.09) 0.134
Visuospatial (figure copying)
  Ref: No-FMM − 0.31 (0.15) 0.034 − 0.06 (0.12) 0.619 − 0.82 (0.37) 0.033 0.02 (0.56) 0.968
  Ref: Diffuse-FMM − 0.17 (0.16) 0.296 0.22 (0.19) 0.236 − 0.69 (0.38) 0.079 0.03 (0.39) 0.947
  1. FMM 18F-flutemetamol, SE standard error, CU cognitively unimpaired, aMCI amnestic mild cognitive impairment, ADD Alzheimer’s disease dementia, K-BNT Korean version-Boston Naming Test, CDR-SB Clinical Dementia Rating Scale Sum of Boxes
  2. *Values were adjusted for age and education
  3. p < 0.05 after Bonferroni correction for 4 tests (4 cognitive subdomains)
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