Cognitive trajectories of patients with focal ß-amyloid deposition

Table 2 The rate of cognitive decline in the Focal-FMM uptake compared to the No- or Diffuse- FMM uptake in each cognitive level

	Total (n = 240)		CU (n = 112)		aMCI (n = 78)		ADD (n = 50)
	Beta (SE)	p	Beta (SE)	p	Beta (SE)	p	Beta (SE)	p
*Global cognition (CDR-SB)**
Ref: No-FMM	0.53 (0.20)	0.009	0.22 (0.10)	0.031	0.83 (0.38)	0.028	0.36 (0.98)	0.716
Ref: Diffuse-FMM	− 0.84 (0.22)	< 0.001	− 0.32 (0.16)	0.040	− 0.26 (0.38)	0.505	− 0.86 (0.66)	0.200
Cognitive subdomains
Frontal-executive (Stroop test)
Ref: No-FMM	− 0.09 (0.09)	0.361	0.01 (0.10)	0.944	− 0.39 (0.19)	0.042	0.22 (0.36)	0.543
Ref: Diffuse-FMM	0.17 (0.11)	0.115	0.16 (0.15)	0.281	− 0.22 (0.19)	0.268	0.41 (0.26)	0.12
Language (K-BNT)
Ref: No-FMM	− 0.12 (0.08)	0.133	− 0.08 (0.09)	0.385	− 0.23 (0.17)	0.177	− 0.01 (0.24)	0.976
Ref: Diffuse-FMM	0.15 (0.09)	0.088	− 0.15 (0.14)	0.263	0.02 (0.17)	0.915	0.24 (0.17)	0.169
Memory (verbal memory)
Ref: No-FMM	− 0.15 (0.08)	0.064	− 0.07 (0.11)	0.544	− 0.32 (0.18)	0.078	− 0.14 (0.13)	0.288
Ref: Diffuse-FMM	0.11 (0.09)	0.244	0.53 (0.17)	0.003†	− 0.001 (0.19)	0.996	− 0.14 (0.09)	0.134
Visuospatial (figure copying)
Ref: No-FMM	− 0.31 (0.15)	0.034	− 0.06 (0.12)	0.619	− 0.82 (0.37)	0.033	0.02 (0.56)	0.968
Ref: Diffuse-FMM	− 0.17 (0.16)	0.296	0.22 (0.19)	0.236	− 0.69 (0.38)	0.079	0.03 (0.39)	0.947

FMM ¹⁸F-flutemetamol, SE standard error, CU cognitively unimpaired, aMCI amnestic mild cognitive impairment, ADD Alzheimer’s disease dementia, K-BNT Korean version-Boston Naming Test, CDR-SB Clinical Dementia Rating Scale Sum of Boxes
*Values were adjusted for age and education
†p < 0.05 after Bonferroni correction for 4 tests (4 cognitive subdomains)

ISSN: 1758-9193