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Table 1 Demographic, clinical and biomarker characteristics of AD dementia subtypes at baseline

From: Data-driven FDG-PET subtypes of Alzheimer’s disease-related neurodegeneration

  CN group AD group, limbic-predominant (S1) AD group, typical (S2) AD group, cortical-predominant (S3) P value, global comparison (S1, S2 and S3) Pair-wise comparisons
S1 vs S2 S1 vs S3 S2 vs S3
Demographics
n (%) 179 79 (44.6%) 86 (48.6%) 12 (6.8%)     
 Age, years 73.8 (6.5) 75.4 (6.9) 73.2 (5.7) 68.0 (7.7) 0.007 0.149 0.015 0.088
 Sex, female (%) 50% 49% 38% 50% 0.332    
 Education, years 16.6 (2.5) 15.4 (3.1) 15.5 (2.6) 16.3 (2.6) 0.544    
Cognition
 MMSE 29.1 (1.2) 23.4 (1.9) 23.2 (2.2) 22.0 (2.2) 0.037 0.798 0.165 0.200
 ADNI-MEM 1.04 (0.62) − 0.85 (0.55) − 0.90 (0.49) − 1.31 (0.44) 0.012 1 0.025 0.028
 ADNI-EF 0.92 (0.83) − 0.65 (0.86) − 1.11 (0.89) − 1.73 (0.81) < 0.001 0.002 < 0.001 0.043
 ADNI-DIFF 0.13 (0.72) − 0.21 (0.69) 0.21 (0.85) 0.41 (0.74) < 0.001 0.004 0.029 0.723
 ADNI-VS 0.23 (0.59) − 0.42 (0.8) − 0.67 (1.01) − 1.15 (1.08) 0.085    
 ADNI-Lan 0.89 (0.71) − 0.63 (0.95) − 0.83 (0.88) − 1.11 (0.78) 0.03 0.406 0.406 0.588
Biomarkers
 APOE ε4 (%) 28% 81% 79% 58% 0.222    
 AV45-PET SUVR 1.11 (0.18) 1.43 (0.14) 1.47 (0.17) 1.4 (0.17) 0.145    
 CSF Aβ, pg/ml 1392 (663) 598 (163) 585 (225) 629 (169) 0.686    
 CSF t-tau, pg/ml 236 (92) 374 (143) 374 (154) 402 (124) 0.978    
 CSF p-tau, pg/ml 22 (9) 38 (16) 37 (16) 39 (14) 0.881    
 HV 4.97 (0.38) 4.05 (0.51) 4.1 (0.38) 4.46 (0.46) 0.09    
 CTV 87.39 (6.28) 75.84 (6.95) 73.99 (6.23) 70.04 (5.88) 0.006 0.136 0.026 0.136
 HV:CTV ratio 57.11 (5.29) 53.67 (7.57) 55.74 (6.61) 64.29 (10.08) < 0.001 0.136 < 0.001 < 0.001
 WMH 6.1 (10.4) 8.0 (10.0) 5.8 (7.9) 8.1 (12.7) 0.262    
  1. Values for variables are presented as percentages (for gender and APOE ε4 genotype) or means with standard deviation in parentheses. Missing values are excluded (for numbers of missing values per subtype see Supplementary Table 8). In case of significant main effects, subtypes were compared with the post hoc pairwise t tests with FDR correction. Please note that composite cognitive scores have arbitrary units on scales centred on the original test samples used to develop these scores (including patients and healthy controls) [18,19,20]
  2. S1 limbic-predominant subtype, S2 typical subtype, S3 cortical-predominant subtype, HV hippocampal grey matter volume scaled to total intracranial volume, CTV cortical composite grey matter volume scaled to total intracranial volume
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