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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Data-driven FDG-PET subtypes of Alzheimer’s disease-related neurodegeneration

Fig. 2

Hypometabolic FDG-PET patterns of subtypes of patients with prodromal AD. Voxel-wise hypometabolic patterns of the four prodromal AD subtypes as compared to the healthy control group. FDG-PET scans were scaled to the average pons signal prior to analysis, and age, gender, and years of education were used as covariates. Statistical parametric maps of the group differences were converted into Cohen’s d effect size maps to allow for a better comparison of the patterns across the unevenly sized subgroups. Please note that the effect size scale differs from the scale used in Fig. 1 as it has been adapted to optimally display the differential patterns that define the subtypes at the prodromal disease stage. Supplementary Figure 4 provides an illustration of the hypometabolic patterns in the prodromal group when using the same effect size scale as in the AD dementia group

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