Fig. 1

Hierarchical clustering dendrogram and hypometabolic FDG-PET patterns of identified AD subtypes. Dendrogram resulting from Ward’s hierarchical clustering analysis of individual FDG-PET profiles of patients with AD dementia. Brain plots show voxel-wise hypometabolic patterns of the three identified AD subtypes as revealed by statistical comparison to the healthy control group. FDG-PET scans were scaled to the average pons signal prior to the group comparisons, and age, gender, and years of education were used as covariates. Statistical parametric maps of the group differences were converted into Cohen’s d effect size maps to allow for a better comparison of the patterns across the unevenly sized AD subgroups. Subtype patterns at higher clustering solutions are shown in Supplementary Figure 2